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Lowered seizure threshold as a part of the narcotic abstinence syndrome in rats


A decrease in threshold to flurothyl-induced seizures in rats is a sensitive measure of the morphine primary abstinence syndrome. The test is easy to perform, yields highly reproducible results, allows for simple statistical group comparisons and correlates well with the usual methods of assessing withdrawal.

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Adler, M.W., Lin, C., Smith, K.P. et al. Lowered seizure threshold as a part of the narcotic abstinence syndrome in rats. Psychopharmacologia 35, 243–247 (1974).

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Key words

  • Morphine
  • Narcotics
  • Drug Dependence
  • Abstinence Syndrome
  • Seizures