Virchows Archiv A

, Volume 391, Issue 2, pp 217–225 | Cite as

Factor VIII related antigen as an endothelial cell marker in benign and malignant diseases

  • Maxwell Sehested
  • Klaus Hou-Jensen
Original Articles


The presence and distribution of Factor VIII related antigen (FVIIIR:Ag) in formalin fixed, paraffin embedded tissue were studied in benign and malignant vascular tumors, inflammatory vascular diseases, normal tissue from various organs and a number of malignant tumors. The unlabeled peroxidase-anti-peroxidase method was utilized. Immunostaining was observed only in endothelial cells, in tumor cells of endothelial cell origin and in megakaryocytes and platelets. The staining method gave a distinct picture of the vascular pattern in all types of tissue examined. The demonstration of FVIIIR: Ag by means of the immunoperoxidase technique is considered a valuable method in diagnosing tumors of vascular origin. The method also facilitates detection of vascular invasion of malignant tumors in small caliber vessels.

Key words

Factor VIII Endothelial cells Malignant tumors 


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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • Maxwell Sehested
    • 1
  • Klaus Hou-Jensen
    • 1
  1. 1.Department of PathologyFinsen InstituteCopenhagenDenmark

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