Psychopharmacologia

, Volume 33, Issue 4, pp 355–364 | Cite as

(−)δ9 THC as an hypnotic

An experimental study of three dose levels
  • Kenneth Cousens
  • Alberto DiMascio
Human Pharmacology

Abstract

(−)δ9 THC was found to significantly decrease the time it takes to fall asleep in physically healthy insomniacs. Once asleep, interruptions of sleep were not significantly altered over the whole night. The (−)δ9 THC tended to be associated with some decrease in awakenings in the first half of the night.

The primary side effect experienced by the subjects at all dose levels in the Pre-Sleep phase was temporal disorganization and mood alterations. There was an increase in intensity of side effects and number of subjects affected with increasing dosage.

The most significant side effect, however, was a “hangover” phenomenon, or continued “high” the next day, with some residual of temporal disorganization. It increased in intensity and duration with increase in dosage. This “hangover” seems severe enough to eliminate the consideration of the 30 mg dose range of (−)δ9 THC for clinical use as an hypnotic.

Key words

THC Tetrahydrocannabinol Hypnotics Sleep-Induction 

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References

  1. 1.
    Hollister, L. E.: Marijuana in man: Three years later (1970)Google Scholar
  2. 2.
    Grinspoon, L.: Marihuana reconsidered. Cambridge: Harvard University Press 1971Google Scholar
  3. 3.
    Isbell, H., Jasinski, D. J., Gorodetzsky, C. W.: Studies on tetrahydrocannabinol. Psychopharmacologia (Berl.) 11, 184 (1967)Google Scholar
  4. 4.
    Hollister, L. E., Moore, F., Kantor, S.: Tetrahydrocannabinol, synhexyl and marihuana extract administered orally in mans catecholamine excretion, plasma cortisol levels and platelet serotonin content. Psychopharmacologia (Berl.) 17, 354–360 (1970)Google Scholar
  5. 5.
    Melges, F. T., Tinklenberg, J. R., Hollister, L. E.: Temporal disintegration and depersonalization during marihuana intoxication. Arch. gen. Psychiat. 23, 204–210 (1970)Google Scholar
  6. 6.
    Kales, A., Hanley, J., Rickles, W.: Effects on marihuana administration and withdrawal in chronic users and naive subjects. Presented at First International Congress of the Association of the Psychophysiological Study of Sleep. June 1971Google Scholar
  7. 7.
    Personal communication from L. E. Hollister, June 1971Google Scholar
  8. 8.
    Melges, F. T., Tinklenberg, J., Hollister, L. E.: Marihuana and temporal disintegration. Science 168, 1118–1120 (1970)Google Scholar
  9. 9.
    Melges, F. T., Tinklenberg, J. R., Hollister, L. E.: Marihuana and the temporal span of awareness. Arch. gen. Psychiat. 24, 564–567 (1971)Google Scholar
  10. 10.
    Pivik, R. T., Zarcone, V., Dement, W. C.: Delta-9 tetrahydrocannabinol and synhexl: Effects on human sleep patterns. (In press.)Google Scholar

Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • Kenneth Cousens
    • 1
    • 2
  • Alberto DiMascio
    • 1
    • 2
  1. 1.Napa State HospitalCalifornia
  2. 2.Department of Mental HealthBoston State HospitalBoston

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