Cancer and Metastasis Reviews

, Volume 15, Issue 2, pp 231–236 | Cite as

Treating cancer by inhibiting angiogenesis: new hopes and potential pitfall

  • J. Rak
  • R. S. Kerbel
Tumor Angiogenesis

Summary

Angiogenesis is essential for progressive solid tumor growth and thus constitutes a very promising therapeutic target. Recent developments in understanding of the molecular mechanisms involved in tumor blood vessel formation provides a rational basis for anti-angiogenic drug development, especially of more selective and effective agents. However, for the very same reason, it is time to think more critically about some of the potential pitfalls and difficulties associated with this treatment strategy and of research needed to define realistic expectations in this area.

Key words

angiogenesis dependence oncogenes VEGF 

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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • J. Rak
    • 1
  • R. S. Kerbel
    • 1
  1. 1.Reichmann Research Building, Division of Cancer Biology ResearchSunnybrook Health Science CentreTorontoCanada

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