Primary mineralization in the interface between bone and methyl methacrylate implants in rat mandibles
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Summary
Self curing polymethylmethacrylate implants were administered into rat mendibular bone. Tissue reaction was studied after different periods with light microscopy and transmission and scanning electron microscopy. Formation of fibrous tissue in the interface between implant and bone was associated with initial bone resorption and followed by the occurrence of primary calcification in a collagen rich matrix after 4–8 weeks. The features of primary mineralization comprised appearance of hydroxyapatite crystals within matrix vesicles and formation of calcospheritic structures. The occurrence of calcifying fronts after the intraosseous administration of polymethylmethacrylate suggests a favourable relationship between bone and the implant material.
Keywords
Scanning Electron Microscopy Bone Resorption Methacrylate Hydroxyapatite PolymethylmethacrylateZusammenfassung
Selbstpolymerisierende Polymethylmethakrylat-Implantate wurden in den Knochen des Unterkiefers bei der Ratte eingebracht. Die Gewebsreaktion wurde nach verschiedenen Zeitspannen lichtmikroskopisch und raster-elektronenmikroskopisch untersucht. In der Kontaktfläche zwischen Implantat und Knochen trat anfänglich eine Knochenresorption und die Einlagerung von Bindegewebe auf, die von einer Verkalkung in einer kollagenreichen Matrix nach 4–8 Wochen abgelöst wurde. Die Zeichen der primären Mineralisation umfaßten auch das Auftreten von Hydroxy-Apatit-Kristallen in Vesikeln der Matrix und die Bildung von Calcopherit-Strukturen. Durch das Auftreten von Verkalkungsfronten nach der intraossalen Einverleibung von Polymethylmethakrylat wird eine günstige Wechselbeziehung zwischen dem Knochen und dem Implantatmaterial nahegelegt.
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