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Mycopathologia

, Volume 114, Issue 2, pp 89–91 | Cite as

HLA antigens in Brazilian patients with paracoccidioidomycosis

  • L. Z. Goldani
  • C. M. C. Monteiro
  • E. A. Donadi
  • R. Martinez
  • J. C. Voltarelli
Article

Abstract

Eighty patients with paracoccidioidomycosis were typed for 43 HLA specificities from loci A, B, C and DR. A highly significant increased frequency of HLA-B40 (relative risk 29.2) and HLA-Cw 1 (relative risk 8.8) were found in patients compared to control subjects. The frequencies HLA-A2, B7 and B21 were also increased in patients and haplotypes-B40-Cw1 and -A2-B40 were positively correlated with the disease. DR antigen frequencies were not significantly altered in the patients and evidence of a protective effect was not found for any of the 43 antigens tested. These findings further support the involvement of the HLA system in the genetic susceptibility to paracoccidioidomycosis and the importance of ethnic variability in this association.

Key words

Paracoccidioidomycosis P. brasiliensis 

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Copyright information

© Kluwer Academic Publishers 1991

Authors and Affiliations

  • L. Z. Goldani
    • 1
  • C. M. C. Monteiro
    • 1
  • E. A. Donadi
    • 1
  • R. Martinez
    • 1
  • J. C. Voltarelli
    • 1
  1. 1.Department of Internal Medicine, Ribeirão Preto School of MedicineUniversity of São PauloSão PauloBrazil

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