Current Genetics

, Volume 6, Issue 2, pp 167–170 | Cite as

Allele-specific suppression of a cell cycle mutant of S. cerevisiae

  • K. M. V. Richmond
  • D. H. Williamson
Short Communication


A cell cycle (cdc) mutant of Saccharomyces cerevisiae is described which fails to complement cdc27-1 described by Hartwell et al. 1973), and is designated cdc27–47. Whereas cdc27-1 behaves as a single Mendelian gene (Hartwell et al. 1973), cdc27–47 requires the presence of an additional unlinked gene for expression of temperature-sensitivity. This gene, designated sts47, is present in some, but not all, laboratory wild-type strains. Expression of cdc27-1 is not influenced by STS47. A model for suppression is proposed involving the modification of conformation within a structural or enzyme complex.

Key words

S. cerevisiae Cell cycle Suppression 


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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • K. M. V. Richmond
    • 1
  • D. H. Williamson
    • 1
  1. 1.National Institute for Medical ResearchLondonGreat Britain

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