, Volume 72, Issue 1, pp 21–26 | Cite as

The effects of Δ9-tetrahydrocannabinol alone and in combination with cannabidiol on fixed-interval performance in rhesus monkeys

  • Kathleen T. Brady
  • Robert L. Balster
Original Investigations


It has been reported that cannabidiol (CBD) antagonizes the effects of Δ9-tetrahydrocannabinol (THC) on operant behavior in rats and pigeons. We have replicated this finding with rhesus monkeys. Four rhesus monkeys were trained to lever press on a fixedinterval 5-min schedule of food presentation with a 1-min limited hold and 1-min time out between successive intervals. The effects of 0.3 and 1.0 mg/kg THC alone were determined three times during the experiment; before the CBD-THC interaction, after the CBD-THC interaction and once with the CBD vehicle. A dose of 30 mg/kg CBD, which alone resulted in a 24% reduction in responding, completely antagonized the response rate reduction produced by 0.3 mg/kg THC. The effects of THC revealed a rate-dependent effect that did not conform to the log-linear rate-dependency plots described for most other drugs.

Key words

Cannabinols Tetrahydrocannabinol Cannabidiol Operant behavior Fixed-interval schedule Interaction Rate-dependency Monkeys 


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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Kathleen T. Brady
    • 1
  • Robert L. Balster
    • 1
  1. 1.Pharmacology Department, Medical College of VirginiaVirginia Commonwealth UniversityRichmondUSA

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