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Effects of chronic Δ9-tetrahyrocannabinol administration on schedule-controlled behavior of pigeons: Cross-tolerance to pentobarbital and barbital

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Abstract

Pigeons responding under a variable-interval (VI) 75-s schedule of food presentation were used to study cross-tolerance from Δ9-tetrahyrocannabinol (Δ9-THC) to pentobarbital and barbital. After initial dose-effect functions for pentobarbital and barbital were determined, the birds received Δ9-THC injections for 6 weeks. This chronic administration regimen resulted in a greater than 100-fold tolerance to Δ9-THC. Redetermination of the pentobarbital and barbital dose-effect functions during the chronic Δ9-THC regimen revealed statistically significant shifts to the right for the pentobarbital (0.191 log unit) and barbital (0.078 log unit) dose-effect curves. All six birds showed tolerance to pentobarbital, while four of the six showed tolerance to barbital. Blood barbital levels before and after chronic Δ9-THC administration did not differ significantly. Tolerance to Δ9-THC was more prolonged and of much greater magnitude than the cross-tolerance to pentobarbital or barbital. The results demonstrate that cross-tolerance can develop from Δ9-THC to a barbiturate that normally undergoes little metabolism.

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References

  1. Colquhoun D (1971) Lectures on biostatistics. Oxford Univ. Press, Oxford

  2. Ferster CB, Skinner BF (1957) Schedules of reinforcement. New York: Appleton-Century-Crofts

  3. Manning FJ (1976) Role of experience in acquisition and loss of tolerance to the effect of Δ9-THC on spaced responding. Pharmacol Biochem Behav 5:269–273

  4. Maynert EW, van Dyke HB (1949) The metabolism of barbiturates. Pharmacol Rev 1:217–242

  5. Maynert EW, van Dyke HB (1950) The absence of localization of barbital in divisions of the central nervous system. J Pharmacol Exp Ther 98:184–187

  6. McMillan DE, Dewey WL, Harris LS (1971) Characteristics of tetrahydrocannabinol tolerance. Ann NY Acad Sci 191:83–99

  7. McMillan DE, Harris LS, Frankenheim JM, Kennedy JS (1970) 1-Δ9-trans-Tetrahydrocannabinol in pigeons: tolerance to the behavioral effects. Science 169:501–503

  8. McMillan DE, Leander JD, Dudley KH (1980) Effects of drugs on behavior in pigeons tolerant to Δ9-tetrahydrocannabinol. J Pharmacol Exp Ther 212:85–90

  9. Stern EL, Caron GP (1977) Measuring barbiturates, sedatives and anticonvulsion in serum by gas-liquid chromatography. Am J Med Technol 43:834–842

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Correspondence to L. D. Chait.

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Chait, L.D., Brocco, M.J. & McMillan, D.E. Effects of chronic Δ9-tetrahyrocannabinol administration on schedule-controlled behavior of pigeons: Cross-tolerance to pentobarbital and barbital. Psychopharmacology 75, 1–4 (1981). https://doi.org/10.1007/BF00433491

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Key words

  • Pigeon
  • Schedule-controlled behavior
  • Tolerance
  • Cross-tolerance
  • Δ9-THC
  • Pentobarbital
  • Barbital