Sympathoadrenal activity, adrenocortical function and androgenic status were studied in five well-trained mountaineers during the different phases of a mountaineering expedition during the ascent of Mt Pabil (7,102 m) in the Ganesh Himal massif. Sympathoadrenal activity was evaluated by measuring urinary excretion of adrenaline, noradrenaline, metanephrines, and vanillinmandelic acid. Adrenocortical function was assessed by measuring urinary excretion of free cortisol, 17 OHCS (17-hydroxycorticosteroids) and androgenic status by measuring testosterone glucuronide, Adiol (5α-androstane-3α, 17Β diol) and 17KS (17-ketosteroids).
Reference values were obtained at Chamonix at 1,037 m during rest. During trekking noradrenaline increased significantly while Adiol and 17-KS decreased. The fall in the urinary androgenic pool persisted during the next phases of the expedition. At base camp (4,800 m) noradrenaline, its metabolites and free cortisol increased mainly during physical activity. Above 6,000 m, adrenaline, noradrenaline, their metabolites, free cortisol and 17-OHCS reached a maximum value. During the return to sea level, the urinary level of these parameters was still high.
The drop in the urinary androgenic pool observed during trekking and exposure to high altitude confirms results obtained in other studies on prolonged efforts. This hypoandrogenicity may play an important role in the metabolic adaptations as well as in the mental state of the climbers. The increase of sympathoadrenal activity and of adrenocortical function may be considered as a regulatory element in the adaptative response to hypoxia and other stressors proper to high altitude.
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Allen WH (1950) A simple method for analyzing complicated absorption curves, of use in the colorimetric determinations of urinary steroids. J Clin Endocrinol 10: 71–83
Bangham CRM, Hackett PH (1978) Effects of high altitude on endocrine function in the sherpas of Nepal. J Endocrinol 79: 147–148
Crapo L (1979) Cushing's syndrome: a review of diagnostic tests. Metabolism 28: 955–977
Cunningham WL, Becker EJ, Kreuzer F (1965) Catecholamines in plasma and urine at high altitude. J Appl Physiol 20: 607–610
Ehrenkranz J, Bliss E, Sheard MH (1974) Plasma testosterone: correlation with aggressive behavior and social dominance in man. Psychosom Med 36: 469–475
Guerra-Garcia R (1971) Testosterone metabolism in men exposed to high altitude. Acta Endocrinol Panam 2: 55
Guilland JC, Caillard B, Putelat R, Klepping C, Klepping J, Malval M (1980) Activité dopamine-Β-hydroxylase plasmatique après ablation d'un phéochromocytome. Ann Endocrinol 41: 43–49
Gupta RN, Price D, Keane PM (1973) Modified Pisano method for estimating urinary metanephrines. Clin Chem 19: 611–614
Hartley LH, Mason JW, Hogan RP, Jones LG, Kotchen TA, Mougey EH, Wherry FE, Pennington LL, Rickets PT (1972) Multiple hormonal responses to graded exercise in relation to physical training. J Appl Physiol 33: 602–606
Herry JP, Grevy A, Pollet-Villard Y, Dumas JP, Chalopin C, Klepping J (1980) Stress des hautes altitudes. Tentative d'ascension du Dhaulagiri (8172 m) — Automne 1978. Tempo Med [Paris] 49: 66–70
Herry JP, Grevy A, Pollet-Villard Y, Begue RJ, Guilland JC, Dumas JP, Klepping J (1981) Sympathoadrenal and adrenocortical activity at varying high altitudes. In: Poortmans J, Niset G (eds). Biochemistry of exercise IV-B. University Park Press, Baltimore, p 121 [Abstract]
Hoon RS, Sharma SC, Balasubramanian V, Chadha KS (1977) Urinary catecholamine excretion on induction to high altitude (3,658 m) by air and road. J Appl Physiol 42: 728–730
Humpeler E, Skrabal F, Bartsch G (1980) Influence of exposure to moderate altitude on the plasma concentration of cortisol, aldosterone, renin, testosterone, and gonadotropins. Eur J Appl Physiol 45: 167–176
Klein KE (1963) Data presented during discussion. In: Weihe WH (ed) The physiological effects of high altitude. MacMillan, New York, pp 136–137
Lau C, Timiras PS (1972) Adrenocortical function in hypothalamic deafferented rats maintained at high altitude. Am J Physiol 222: 1040–1042
Levi L (1972) Methodological considerations in psychoendocrine research. In: Stress and distress in response to psychosocial stimuli. Acta Med Scand [suppl] 528: 28–54
Malhotra MS, Selvamurthy W, Purkyastha SS, Mukherjee AK, Mathew L, Dua GL (1976) Responses of the autonomic nervous system during acclimatization to high altitude in man. Aviat Space Environ Med 47: 1076–1079
Mason J, Hartley LH, Kotchen TA, Mougey EH, Ricketts PT, Jones LG (1973) Plasma cortisol and norepinephrine responses in anticipation of muscular exercise. Psychosom Med 35: 406–414
McKinnon PCS, Monk-Jones ME, Fotherby K (1963) A study of various indices of adrenocortical activity during 23 days at high altitude. J Endocrinol 26: 555–566
Moncloa F, Donayre J, Sobrevilla LA, Guerra-Garcia R (1965) Endocrine studies at high altitude. II Adrenal cortical function in sea-level natives exposed to high altitudes (4,300 m) for two weeks. J Clin Endocrinol Metab 25: 1640–1642
Moncloa F, Velasco I, Beteta L (1968) Plasma cortisol concentration and disappearance rate of 4-14C-cortisol in newcomers to high altitude. J Clin Endocrinol Metab 28: 379–382
Morville R, Pesquies PC, Guezennec CY, Serrurier BD, Guignard M (1979) Plasma variations in testicular and adrenal androgens during prolonged exercise in man. Ann Endocrinol 40: 501–510
Murphy BEP (1967) Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein binding radioassay. J Clin Endocrinol Metab 27: 973
Petropoulos EA, Timiras PS (1974) Biological effects of high altitude as related to increased solar radiation, temperature fluctuations and reduced partial pressure of oxygen. Prog Biometeorol 1: 295–328, 646–662
Picon-Reategui E (1962) Studies on the metabolism of carbohydrates at sea level and at high altitudes. Metab Clin Exptl 11: 1148–1154
Porter CC, Silber RH (1950) A quantitative colour reaction for cortisone and related 17,12-dihydroxy-20-ketosteroids. J Biol Chem 185: 201–207
Pugh LGCE (1962) Physiological and medical aspects of the Himalayan scientific and mountaineering expedition, 1960–1961. Br Med J 2: 621–627
Riggin RM, Kissinger PT (1977) Determination of catecholamines in urine by reverse-phase liquid chromatography with electrochemical detection. Anal Chem 49: 2109–2111
Sailer E, Verzar F (1950) Die Ausscheidung von Corticosteroiden in Ruhe, bei Muskelarbeit und in der Höhe. Helv Phys Acta 8: C72-C74
Selye H (1936) A syndrome produced by diverse nocuous agents. Nature 138: 32
Soldin SJ, Hill HC (1980) Simultaneous liquid Chromatographic analysis for 4-hydroxy-3-methoxymandelic acid and 4-hydroxy-3-methoxyphenylacetic acid in urine. Clin Chem 26: 291–294
Surks MI, Beckwitt HJ, Chidsey CA (1967) Changes in plasma thyroxine concentration and metabolism, catecholamine excretion and basal oxygen consumption in man during acute exposure to high altitude. J Clin Endocrinol Metab 27: 789–799
Timiras PS, Pace NG, Hwang CA (1957) Plasma and urine 17-hydroxycorticosteroid and urine 17-ketosteroid levels in man during acclimatization to high altitude. Fed Proc 16: 340
Vander AJ, Moore LG, Brewer G, Menon KMJ, England BG (1978) Effects of high altitude on plasma concentrations of testosterone and pituitary gonadotropins in man. Aviat Space Environ Med 49: 356–357
Ward M (1975) Mountain medicine. Granada Publishing, London
Wilkerson JE, Horvath SM, Gutin B (1980) Plasma testosterone during treadmill exercise. J Appl Physiol 49: 249–253
Wright F, Mowszowicz I, Mauvais-Jarvis P (1978) Urinary 5α-androstane-3α,17Β-diol radioimmunoassay: a new clinical evaluation. J Clin Endocrinol Metab 47: 850–854
This work was supported in part by a grant from the Direction des Recherches, Etudes et Techniques des Armées (Contract 80.1114)
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Guilland, J.C., Moreau, D., Malval, M. et al. Evaluation of sympathoadrenal activity adrenocortical function and androgenic status in five men during a Himalayan mountaineering expedition (ascent of Mt Pabil, 7,102 m, 23,294 ft). Europ. J. Appl. Physiol. 52, 156–162 (1984). https://doi.org/10.1007/BF00433385
- High altitude
- Adrenal cortex hormones