Four benzodiazepine tranquilizers have been tested, alone or in combination with amphetamine, on spontaneous locomotor activity of C57BL/6 mice. Amphetamine-induced locomotor stimulation was enhanced by chlordiazepoxide, diazepam, and medazepam, but not by bromazepam. The results indicate that benzodiazepine derivatives may be somewhat differentiated on the basis of their interactions with amphetamine.
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Cooper SJ (1979) Behavioural studies of drug interactions. In: Brown K, Cooper SJ, (eds) Chemical influences on behaviour. Academic Press, London, p 533
Costa E, Guidotti A (1979) Molecular mechanisms in the receptor action of benzodiazepines. Ann Rev Pharmacol Toxicol 19:531–545
Davies C, Sanger DJ, Steinberg H, Tomkiewicz M, U'Prichard DC (1974) Lithium and α-methyl-p-tyrosine prevent “manic” activity in rodents. Psychopharmacologia 36:263–274
Oliverio A, Eleftheriou BE, Bailey DW (1973) Exploratory activity: Genetic analysis of its modification by scopolamine and amphetamine. Physiol Behav 10:893–899
Rushton R, Steinberg G, Tomkiewicz M (1973) Effects of chlordiazepoxide alone and in combination with amphetamine on animal and human behaviour. In: Garattini S, Mussini E, Randall LO (eds) The benzodiazepines. Raven, New York, p 355
Sansone M (1975) Benzodiazepines and amphetamine on avoidance behaviour in mice. Arch Int Pharmacodyn 218:125–132
Sansone M, Hano J (1979) Enhancement by chlordiazepoxide of the anticholinergic-induced locomotor stimulation in mice. Psychopharmacology 64:181–184
Vetulani J, Sansone M (1978) Stimulatory effect of chlordiazepoxide on locomotor activity in mice: importance of noradrenergic transmission. Pol J Pharmacol Pharm. 30:791–798
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Sansone, M. Influence of benzodiazepine tranquilizers on amphetamine-induced locomotor stimulation in mice. Psychopharmacology 71, 63–65 (1980). https://doi.org/10.1007/BF00433253
- Locomotor activity