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Psychopharmacology

, Volume 65, Issue 2, pp 155–159 | Cite as

The involvemet of serotonergic neurons in the central nervous system as the possible mechanism for slow head-shaking behavior induced by methamphetamine in rats

  • Takeshi Honma
  • Hideaki Fukushima
Original Investigations

Abstract

Following the IV administration of d-methamphetamine (MA), rats showed slow head shaking (SHS) and stereotyped gnawing (SG) behaviors in a dose-dependent manner. Methysergide, cyproheptadine, and p-chlorophenylalanine given intracerebroventricularly (ICV) or systemically significantly blocked SHS behavior induced by 10 mg/kg MA. Combined administration of l-5-hydroxytryptophan and peripheral decarboxlase inhibitor (Ro 4-4602) enhanced SHS behavior. Tyrosine hydroxylase inhibitor (H44/68) blocked SG behaviors, but dopamine-β-hydroxylase inhibitors (FLA 63 and U-14, 624) and combined administration of l-3,4-dihydroxyphenylalanine and Ro 4-4602 enhanced it. These drugs did not affect SHS behavior. Phentolamine, phenoxybenzamine, clonidine, isoproterenol, and propranolol given ICV or systemically showed no effect on either SHS or SG behaviors. These results suggest that SHS behavior is produced by the activation of serotonergic neurons in the central nervous system and are consistent with the view that SG behaviors are mediated through the release of dopamine. Some neuroleptics inhibited SHS as well as SG behaviors, but the order of inhibitory activity of neuroleptics on SHS behavior was quite different from their effects on SG behaviors induced by MA or apomorphine.

Key words

d-Methamphetamine Slow head shaking Stereotyped gnawing Serotonin Dopamine Neuroleptics 

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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • Takeshi Honma
    • 1
  • Hideaki Fukushima
    • 1
  1. 1.Research and Development Center, Pharmaceuticals DivisionSumitomo Chemical Co., Ltd.Takarazuka, HyogoJapan

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