, Volume 79, Issue 1, pp 29–31 | Cite as

Drug reinstatement of heroin-reinforced responding in the rat

  • Harriet de Wit
  • Jane Stewart
Original Investigations


Non-contingent, ‘priming’ IV drug injections led to reinstatement of heroin-reinforced responding after a period of extinction. Rats implanted with IV catheters were trained to self-administer heroin (100 μg/kg/infusion diacetylmorphine HCl) and were given test sessions consisting of a period of self-administration followed by extinction conditions. ‘Priming’ infusions of heroin and other drugs were presented during extinction and lever pressing following the injection was observed. Priming injections of 50, 100 and 200 μg/kg heroin effectively restored responding after a period of extinction. Morphine and, to a lesser extent, amphetamine and apomorphine also reinstated heroin-reinforced responding whereas cocaine and clonidine did not. These results may help our understanding of ‘relapse of drug-taking’ behavior.

Key words

Heroin self-administration Reinstatement Priming Relapse of drug-taking behavior 


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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Harriet de Wit
    • 1
  • Jane Stewart
    • 1
  1. 1.Department of PsychologyConcordia UniversityMontrealCanada
  2. 2.Department of PsychiatryUniversity of ChicagoChicagoUSA

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