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Granularzelltumor (GranulÄres Neurom Feyrter) und Schwannsche Phagen

Elektronenoptische Untersuchung von 3 FÄllen

Granular cell tumor and the phagocytozing form of Schwann cells

Electron microscopic examinations of 3 cases

Summary

In granular cell tumors, the granule-containing tumor cells and their processes form rounded complexes surrounded by a common bounding membrane. In the tumor, these complexes are closely related to the peripheral nerves and are seen in the perineurium and in the endoneurium. In addition, there are mixed complexes composed both of Schwann cells and granular tumor cells: the two types of cells are in close contact with each other and are also surrounded by a common bounding membrane. Furthermore, there one contacts between granular tumor cells and axons. These observations strongly suggest the existence of a relationship between Schwann cells and the cells of granular cell tumors.

A comparison between the granular tumor cells and the phagocytic forms of Schwann cells reveals striking similarities: the granular cell tumor complexes are comparable with the Büngner bands of phagocytozing Schwann cells. A relationship between granular cell tumors and the phagocytozing form of Schwann cells is therefore assumed.

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Literatur

  1. Abrikossoff, A.: über Myome ausgehend von der quergestreiften willkürlichen Muskulatur. Virchows Arch. path. Anat. 260, 215–238 (1926)

  2. Abrikossoff, A.: Weitere Untersuchungen über Myoblastenmyome. Virchows Arch. path. Anat. 280, 723–740 (1931)

  3. Allt, G.: Pathology of the peripheral nerve. In: The peripheral nerve (Landon, D.N., Ed.) S. 666–739. London: Chapman and Hall 1976

  4. Bangle, R., Jr.: An early granular-cell myoblastoma confined within a small peripheral myelinated nerve. Cancer 6, 790–793 (1953)

  5. Caputo, R., Bellone, A.G., Tagliavini, R.: Ultrastructure of the granular cell myoblastoma. Arch. Derm. Forsch. 242, 127–136 (1972)

  6. Enzinger, F.M., Lattes, R., Torloni, H.: Histological typing of soft tissue tumors. In: International classification of tumors, vol. 3. Geneva: World Health Organisation 1969

  7. Feyrter, F.: über eine eigenartige Geschwulstform des Nervengewebes im menschlichen Verdauungsschlauch. Virchows Arch. path. Anat. 295, 480–501 (1935)

  8. Feyrter, F.: über die granulÄren neurogenen GewÄchse. Beitr. path. Anat. 110, 181–208 (1949)

  9. Feyrter, F.: über die granulÄren Neurome (sog. Myoblastenmyome). Virchows Arch. path. Anat. 322, 66–72 (1952)

  10. Fisher, E.R., Wechsler, H.: Granular cell myoblastoma — a misnomer. Cancer (Philad.) 15, 936–954 (1962)

  11. Fust, I.A., Custer, R.P.: On the neurogenesis of so-called granular cell myoblastoma. Amer. J. Clin. Path. 19, 522–535 (1949)

  12. Garancis, J.C., Komorowski, R.A., Kuzma, J.F.: Granular cell myoblastoma. Cancer (Philad.) 25, 542–550 (1970)

  13. Hager, H.: Allgemeine morphologische Pathologie des Nervensystems, HB d. Allg. Pathologie, Bd. III/3 (Altmann, H.W., Büchner, F., Cottier, H., Holle, G., Letterer, E., Masshoff, W., Mersen, H., Roulet, F., Seifert, G., Siebert, G., Studer, A., Hrsg.), S. 149–228. Berlin-Heidelberg-New York: Springer 1968

  14. Haisken, W., Langer, D.: Die Submikroskopische Struktur des sog. Myoblastenmyoms — Lipidfibrom — GranulÄres Neurom. Frankfurt. Z. Path. 71, 600–616 (1962)

  15. Harkin, J.C., Reed, R.J.: Tumors of the peripheral nervous system. Atlas of tumor pathology, 2nd ser., Fasc. 3. Washington, D.C.: Publ. Armed Forces Inst. of Path. 1968

  16. Hausman, R.: Granular cells in musculature of the appendix. Arch. Path. 75, 360–372 (1963)

  17. Haustein, U.-F.: Malignes metastasierendes Granularzellmyoblastom Abrikossoff mit symptomatischer Dermatomyositis. Dermatol. Monatsschr. 160, 318–328 (1974)

  18. Holle, G.: über die Deutung der sogenannten Myoblastenmyome als Speicherzellgeschwülste auf Grund einer besonderen fÄrberischen Reaktion. Zbl. allg. Path. path. Anat. 76, 244–247 (1940/41)

  19. Klemperer, P.: Myoblastoma of striated muscle. Am. J. Cancer 20, 324–377 (1934)

  20. Krücke, W.: Pathologie peripherer Nerven, HB d. Neurochirurgie, Bd. VII/3 (Olivecrona, H., Tönnis, W., Krenkel, W., Hrsg.), S. 1–267, Berlin-Heidelberg-New York: Springer 1974

  21. Lauche, A.: Sind die sog. „Myoblastenmyome“ Speicherzellgeschwülste? Virchows Arch. 312, 335–345 (1944)

  22. Leroux, R., Delarue, I.: Sur trois cas de tumeurs à cellules granuleuses de la cavité buccale. Bull. Ass. franc. Cancer 28, 427–447 (1939)

  23. Mackay, B., Elliot, G.B., Mac-Dougall, J.A.: Granular cell myoblastoma of the cystic duct: Report of a case with electronmicroscop observations. Canad. J. Surg. 11, 44–51 (1968)

  24. Magori, A., Szegvári, M.: Rezidivierender und metastasierender Abrikossoff-Tumor der Vulva. Zentralbl. Allg. Pathol. 117, 265–273 (1973)

  25. Martin, I.F., Dina, M.A., Feroldi, I.: La questione dei tumori a cellule granulose: Studio istogenetico e sperimentale sui cosidetti miomi mioblastici di Abrikossoff. Arch. Ital. Anat. Ist. Pat. 24, 205–253 (1951)

  26. Misugi, K., Misugi, N., Newton, W.A.: Ultrastructure of a so called granular cell myoblastoma. Yokohama med. Bull. 18, 255–234 (1967)

  27. Moscovic, E.A., Azar, H.A.: Multiple granular cell tumors (“myoblastomas”): Case report with electron microscopic observations and review of the literature. Cancer (Philad.) 20, 2022–2047 (1967)

  28. Murphy, G.H., Dockerty, M.B., Broder, A.C.: Myoblastoma. Am. J. Path. 25, 1157–1181 (1949)

  29. Nödl, F.: Spezielle Pathologie des neurovegetativen Systems der Haut. Acta Neuroveg. 18, 424–444 (1958)

  30. Nödl, F.: Zur Histogenese der sogenannten Myoblastenmyome. Arch. klin. exp. Dermat. 207, 397–412 (1958)

  31. Pearse, A.G.E.: The histogenesis of granular-cell myoblastoma (granular-cell perineural fibroblastoma) J. Pathol. Bacteriol. 62, 351–367 (1950)

  32. Propst, A., Weiser, G.: Das GranulÄre Neurom Feyrters. Wien. klin. Wschr. 83, 31–33 (1971)

  33. Ratzenhofer, M.: GranulÄre falsche Neurome (sog. Myoblastenmyome) und sekundÄre Wucherung des Deckepithels. Virchows Arch. path. Anat. 320, 138–163 (1951)

  34. Ringertz, N.: über das sog. Myoblastenmyom; mit Beschreibung 7 neuer FÄlle. Acta Path. Microb. Scand. 19, 112–164 (1942)

  35. Sobel, H.I., Churg, J.: Granular cells and granular cell lesions. Arch. Path. 77, 132–141 (1964)

  36. Sobel, H.J., Marquet, E., Avrin, E., Schwarz, R.: Granular cell myoblastoma. Am. J. Path. 65, 69–71 (1971)

  37. Sobel, H.I., Marquet, E., Schwarz, R.: Is Schwannoma related to granular cell myoblastoma? Arch. Pathol. 95, 396–401 (1973)

  38. Usui, M., Ishil, S., Yamawaki, S., Sasaki, T., Minami, A., Hizawa, K.: Malignant granular cell tumor of the radial nerve. Cancer (Philad.) 39, 1547–1555 (1977)

  39. Wegelin, C.: Die Natur der sog. Myoblastentumoren. Schweiz, Z. Path. Bakter. 10, 631–653 (1947)

  40. Weiser, G., Propst, A.: Elektronenoptische Untersuchung zur Histogenese des GranulÄren Neuroms. Virchows Arch. Abt. A Path. Anat. 358, 193–204 (1973)

  41. Weiser, G.: Zur Histogenese des Neurinoms (Elektronenoptische Untersuchung von 10 FÄllen). Virchows Arch. A Path. Anat. and Histol. 378, 143–151 (1978)

  42. Whitten, J.B.: The fine structure of an intraoral granular cell myoblastoma. Oral. Surg. 26, 202–213 (1968)

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Weiser, G. Granularzelltumor (GranulÄres Neurom Feyrter) und Schwannsche Phagen. Virchows Arch. A Path. Anat. and Histol. 380, 49–57 (1978). https://doi.org/10.1007/BF00432892

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Key words

  • Granular cell tumor
  • Schwannian Origin
  • Phagocytozing Schwann cells
  • Electron Microscopy