The Zurich study

II. The continuum from normal to pathological depressive mood swings
  • J. Angst
  • A. Dobler-Mikola


The longitudinal study of a cohort of 591 men and women aged 20 and 21 years respectively at outset, and 23/24 years at a subsequent investigation, was analyzed for the manifestation of depressive syndromes. The syndromes were grouped according to their duration: 1 week once or twice per year (group B),1 week three or more times per year (C), 2 weeks (D), 4 weeks (E) and 3 months (F). Prevalence rates are given over 1 month, 3 months and 1 year, subdivided by sex. Unexpected identical prevalence rates are found for both sexes up to 3 months. Over 1 year, the ratio shifts to favor the women.

Setting out from the hypothesis of a continuum of depressive mood from normal to pathological, groups B to E were examined with respect to the prevailing symptomatology (assessed with an interview and a self-rating questionnaire, the SCL-90R). We found no relevant qualitative differences, only a trend of somatic symptoms becoming more prominent along with increasing duration of episode. Symptomatology thus does not point to further classification. Other criteria, such as subjective impairment, social impairment, illness behavior, discussing depressive mood with parents/friends/employer, treatment, all favor the assumption of a continuum of depressive syndromes from normal to pathological.

Key words

Epidemiology Longitudinal study Depression Continuum from normal to pathological Sex ratio 


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  1. Akiskal HS, King D, Rosenthal TL, Robinson D, Scott-Strauss A (1981) Chronic depressions. Part I: Clinical and familial characteristics in 137 probands. J Aff Dis 3:297–315Google Scholar
  2. American Psychiatric Association (1980) DSM-III diagnostic and statistical manual of mental disorders, 3rd ednGoogle Scholar
  3. Angst J, Dobler-Mikola A (1984) The definition of depression. In: Garattini S, Tognoni G (eds) Biological markers in mental disorders. J Psychiatr Res (in press)Google Scholar
  4. Angst J, Dobler-Mikola A, Binder J (1984) The Zurich Study—a prospective study of depressive, neurotic and psychosomatic syndromes. I: Problem, methodology. Eur Arch PsychiatrNeurol Sci 234:13–20Google Scholar
  5. Derogatis LR (1977) SCL-90. Administration, scoring and procedures manual-I for the R (revised) version and other instruments of the psychopathology rating scale series. Johns Hopkins University School of Medicine, ChicagoGoogle Scholar
  6. Feighner JP, Robins E, Guze SB, Woodruff RA, Winokur G, Manoz R (1972) Diagnostic criteria for use in psychiatric research. Arch Gen Psychiatr 26:57–63Google Scholar
  7. Lehmann HE (1966) Categories, mechanisms and phenomena. In: Cole JO, Wittenborn JR (eds) Pharmacotherapy of depression. Charles C Thomas, Springfield, Ill, pp 3–29Google Scholar
  8. Spitzer RL, Endicott J, Robins E (1978) Research diagnostic criteria. Arch Gen Psychiatr 35:773–782Google Scholar

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • J. Angst
    • 1
  • A. Dobler-Mikola
    • 1
  1. 1.Zurich, Research DepartmentPsychiatric University HospitalZurichSwitzerland

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