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PRL-8-53: Enhanced learning and subsequent retention in humans as a result of low oral doses of new psychotropic agent

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Abstract

The effect of 3-(2-benzylmethylaminoethyl) benzoic acid methyl ester hydrochloride (PRL-8-53) on learning and on retention of verbal information in human subjects was investigated. Using the serial anticipation method under double-blind conditions it was found that PRL-8-53 causes slight improvement of acquisition. Retention of verbal information was found improved to a statistically significant degree (most P values better than 0.01, some better than 0.001). No significant changes were found for either visual reaction time or motor control after drug when compared with placebo values.

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Authors and Affiliations

  1. Department of Medicinal Chemistry and Department of Psychiatry, Creighton University, 68178, Omaha, Nebraska, USA

    Nikolaus R. Hansl & Beverley T. Mead

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  1. Nikolaus R. Hansl
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  2. Beverley T. Mead
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Hansl, N.R., Mead, B.T. PRL-8-53: Enhanced learning and subsequent retention in humans as a result of low oral doses of new psychotropic agent. Psychopharmacology 56, 249–253 (1978). https://doi.org/10.1007/BF00432846

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  • DOI: https://doi.org/10.1007/BF00432846

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