Advertisement

Virchows Archiv A

, Volume 379, Issue 1, pp 73–83 | Cite as

Neurofibrom und Perineuralzelle

Elektronenoptische Untersuchung an 9 Neurofibromen
  • G. Weiser
Article

Neurofibroma and perineurial cell electron microscopic examinations of 9 neurofibromas

Summary

In neurofibromas type I (plexiform) and type II (diffuse) the Schwann cell is the predominant cell in the neoplastic proliferation. Electron microscopic investigation of a neurofibroma with structures resembling tactile corpuscles (type III) revealed neoplastic proliferation of perineurial instead of Schwann cells. The tactile-like (pseudo-Meissnerian) corpuscles (corpuscules neurofibromateux) are formed by neoplastic perineurial cells. These cells have a tendency to wrap themselves around longitudinal structures, such as collagen fibres or axons, and to come into direct contact with the latter. This close relationship between the axon and the neoplastic perineurial cell, analogous to that between axon and Schwann cell, points to a neuroectodermal origin of the perineurial cell. The electron microscopic appearances suggest that either the Schwann cell or the perineurial cell is the essential neoplastic component of neurofibromas, the fibroblastic proliferation being a secondary phenomenon.

Key words

Neurofibrome Tactile-like corpuscles Perineurial cell Neuroectodermal origin Electron microscopy 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Brögli, M.: Ein Fall von Rankenneurom mit Tastkörperchen. Frankf. Z. Path. 41, 595–610 (1931)Google Scholar
  2. Bruns, L.: Die Geschwülste des Nervensystems. III. Die Geschwülste des extrakraniellen Anteils der Hirnnerven, der peripheren spinalen Nerven und des Plexus. Neurome und paraneurale Geschwülste, S. 419–473, Berlin: S. Karger 1908Google Scholar
  3. Dible, J.H.: Verocay bodies and pseudo-meissnerian corpuscles. J. Path. Bact. 85, 425–433 (1963)Google Scholar
  4. Gamble, H.J., Breathnach, A.S.: An electron microscope study of human foetal peripheral nerve. J. Anat. (London) 99, 573–584 (1965)Google Scholar
  5. Harkin, J.C., Reed, R.J.: Tumors of the peripheral nervous system. Atlas of tumor pathology, 2nd ser., Fasc. 3. Washington, D.C.: Armed Forces Institute of Pathology 1968Google Scholar
  6. Hill, R.P.: Neuroma of Wagner-Meissner tactile corpuscles. Cancer (Philad.) 4, 879–882 (1951)Google Scholar
  7. Jordan, P.: Tastkörperartige Bildungen in einem zelligen Naevus der behaarten Kopfhaut. Zur Kenntnis des Neuronaevus, des Neurinoms, des Psammoms, der Cutis und Pseudo-Cutis verticis gyrata und der Recklinghausen'schen Krankheit. Arch. Derm. Syph. (Berl.) 169, 105–126 (1933)Google Scholar
  8. Jurecka, W., Ammerer, H.P., Lassmann, H.: Regeneration of a transected peripheral nerve. Acta neuropath. (Berl.) 32, 299–312 (1975)Google Scholar
  9. Krücke, W.: Pathologie peripherer Nerven, Handb. d. Neurochirurgie, Bd. VII/3 (Olivecrona, H., Tönnis, W., Krenkel, W. Hrsg.), S. 1–267. Berlin-Heidelberg-New York: Springer 1974Google Scholar
  10. Landon, D.N., Ed.: The peripheral nerve. London: Chapman and Hall 1976Google Scholar
  11. Landon, D.N., Hall, S.: The myelinated nerve fibre. In: The peripheral nerve (Landon, D.N., Ed.), S. 1–105. London: Chapman and Hall 1976Google Scholar
  12. Lassmann, H., Ammerer, H.P.: Schwann cells and perineurium in neuroma. Virchows Arch. Abt. B Zellpath. 15, 313–321 (1974)Google Scholar
  13. Lassmann, H., Jurecka, W., Lassmann, G., Gebhart, W., Matras, H., Watzek, G.: Different types of benign nerve sheath tumors. Virchows Arch. A Path. Anat. and Histol. 375, 197–210 (1977)Google Scholar
  14. Low, F.N.: The perineurium and connective tissue of peripheral nerve. In: The peripheral nerve (Landon, D.N., Ed.) S. 159–187. London: Chapman and Hall 1976Google Scholar
  15. Masson, P.: Tumeurs humaines. — Histologie, diagnostics et techniques, 2. ed, Paris: Maloine 1956Google Scholar
  16. Murray, M.R., Stout, A.P.: Schwann cell versus fibroblast as the origin of the specific nerve sheath tumor. Am. J. Pathol. 16, 41–60 (1942)Google Scholar
  17. Murray, M.R., Stout, A.P.: Characteristics of human Schwann cells in vitro. Anat. Rec., 275–294 (1942)Google Scholar
  18. Nathaniel, E.J.H.: Collagen formation by Schwann cells in regenerating dorsal roots of rats. Anat. Rec. 142, 262, Abstract (1962)Google Scholar
  19. Nathaniel, E.J.H., Pease, D.C.: Collagen and basement membrane formation by Schwann cells during nerve regeneration. J. Ultrastr. Res. 9, 550–560 (1963)Google Scholar
  20. Ochoa, I.: The unmyelinated nerve fibre. In: The peripheral nerve (Landon, D.N., Ed.), S. 106–158. London: Chapman and Hall 1976Google Scholar
  21. Pineda, A.: Electron microscopy of the tumor cells in „neurofibromas“. J. Neuropath. exp. Neurol. 25, 158–159 (1966)Google Scholar
  22. Poirier, J., Escourolle, R., Castaigne, P.: Les neurofibromes de la maladie de Recklinghausen. Etude ultrastructurale et place nosoligique par rapport aux neurinomes. Acta neuropath (Berl.) 10, 279–294 (1968)Google Scholar
  23. Prichard, R.W., Custer, R.Ph.: Pacinian-neurofibroma. Cancer (Philad.) 5, 297–301 (1952)Google Scholar
  24. Rio-Hortega, P. Del: Nomenclatura y classification de los tumores del sistema nervioso. Arch. argent. Neurol. 24, 7–60 (1941)Google Scholar
  25. Rio-Hortega, P. Del: Estudio citologico de los neurofibromas de Recklinghausen (lemmocitomas). Arch. Histol (B. Aires) 1, 373–414 (1943)Google Scholar
  26. Russell, D.S., Rubinstein, L.J.: Pathology of tumors of the nervous system. 4th Ed. London: Edward Arnold 1977Google Scholar
  27. Saxen, E.: Tumours of tactile end-organs. Acta path. microbiol. scand. 25, 66–79 (1948)Google Scholar
  28. Schochet, S.S., Barrett, D.A.: Neurofibroma with aberrant tactile corpuscles. Acta neuropath. (Berl.) 28, 161–165 (1974)Google Scholar
  29. Shantha, T.R., Bourne, G.H.: The perineural epithelium — a new concept. In: The Structure and Function of Nervous Tissue, 1, 379–459 (G.H. Bourne, ed.) New York: Academic Press 1968Google Scholar
  30. Shanthaveerappa, T.R., Bourne, G.H.: The “perineural epithelium”, a metabolically active, continuous protoplasmic cell barrier surrounding peripheral nerve fasciculi. J. Anat. (London) 96, 527–537 (1962)Google Scholar
  31. Shanthaveerappa, T.R., Bourne, G.H.: A perineural epithelium. J. Cell Biol. 14, 343–346 (1962)Google Scholar
  32. Shanthaveerappa, T.R., Bourne, G.H.: New observations on the structure on the Pacinian corpuscle and its relation to the perineural epithelium of peripheral nerves. Am. J. Anat. 112, 97–109 (1963a)Google Scholar
  33. Shanthaveerappa, T.R., Bourne, G.H.: Demonstration of perineural epithelium in vagus nerves. Acta anatomica 52, 95–100 (1963b)Google Scholar
  34. Shanthaveerappa, T.R., Bourne, G.H.: Demonstration of perineural epithelium in whole and sharh peripheral nerves: nature and significance. Nature 199, 577–579 (1963d)Google Scholar
  35. Shanthaveerappa, T.R., Bourne, G.H.: The perineural epithelium of sympathetic nerves and ganglion and its relation to the pia-arachnoid mater of the central nervous system and perineural epithelium of peripheral nerves. Z. Zellforsch. mikroskop. Anat. 61, 742–753 (1964)Google Scholar
  36. Shanthaveerappa, T.R., Bourne, G.H.: Histological and histochemical studies of the choroid of the eye and its relations to the pia-arachnoid mater of the central nervous system and perineural epithelium of the peripheral nervous system. Acta anatomica (Basel) 61, 379–398 (1965)Google Scholar
  37. Shanthaveerappa, T.R., Bourne, G.H.: Perineural epithelium: a new concept of its role in the integrity of the peripheral nervous system. Science 154, 1464–1467 (1966)Google Scholar
  38. Shanthaveerappa, T.R., Hope, J., Bourne, G.H.: Electron microscope demonstration of the perineural epithelium in rat peripheral nerve. Acta anatomica 52, 193–201 (1963)Google Scholar
  39. Stochdorph, O., Meister, P.: Tumoren der Weichgewebe und des peripheren Nervensystems. Int. Acad. Pathol., Germ. Div. 11. Tgg., Bonn 1976Google Scholar
  40. Stout, A.P.: Tumors of the peripheral nervous system. Atlas of tumor pathology, sect. II, fasc. 6. Washington D.C.: Armed Forces Institute of Pathology 1949Google Scholar
  41. Sunderland, S.: The connective tissue of peripheral nerves. Brain 88, 841–854 (1965)Google Scholar
  42. Thomas, P.K., Jones, D.G.: Regeneration of the perineurium after nerve section. J. Anat. (London) 101, 45–55 (1967)Google Scholar
  43. Verneuil, A.A.S.: Observations pour servir à l'histoire des alterations locales des nerfs (Nevr. plexiforme) Arch. gen. Med. II, 537–552 (1861)Google Scholar
  44. Waggener, J.D.: Ultrastructure of benign peripheral nerve sheath tumors. Cancer (Philad.) 19, 699–709 (1966)Google Scholar
  45. Weber, K., Braun-Falco, O.: Zur Ultrastruktur der Neurofibromatose. Hautarzt 23, 116–122 (1972)Google Scholar
  46. Weiser, G.: An electron microscope study of “Pacinian Neurofibroma”. Virchows Arch. A Path. Anat. and Histol. 366, 331–340 (1975)Google Scholar
  47. Weiser, G.: Zur Histogenese des Neurinoms. Virchows Arch. A Path. Anat. and Histol. 378, 143–151 (1978)Google Scholar
  48. Weller, R.O., Cervos-Navarro, J.: Tumors of the peripheral nervous system. In: Pathology of peripheral nerves, S. 154–179. London-Boston: Butterworths 1977Google Scholar

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • G. Weiser
    • 1
  1. 1.Pathologisch-anatomisches Institut der UniversitÄt InnsbruckInnsbruckösterreich

Personalised recommendations