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Fine structure of multiple neonatal haemangioendothelioma of the liver

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Summary

This paper discusses the fine structure of multiple haemangioendothelioma of the liver. There have been no previous reports of electron microscopic studies of this tumour, which was found to be composed of young capillaries continuous in type and varying in calibre. The capillaries were lined by actively proliferating, immature endothelial cells with pericytes forming an integral part of the tumour. Their morphological characteristics indicated intensive protein production. The authors suggest that the active pericytes play a role in the production of reticular fibres of the tumour.

Following corticosteroid therapy, regression of tumour nodules occurred in this case in the interval between surgery and autopsy. This was confirmed by histological studies. The results seem to support the hypothesis that actively proliferating, young endothelial cells show an increased sensitivity to corticosteroids.

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References

  1. Andersen, L., Fejerskon, O., Theilade, J.: Oral giant cell granulomas. An ultrastructural study of the vessels. Acta path. microbiol. scand. Sect. A. 83, 69–76 (1975)

  2. Blumenfeld, T.A., Fleming, I.D., Johnson, W.W.: Juvenile haemangioendothelioma of the liver. Report of a case and review of the literature. Cancer. 24, 853–857 (1969)

  3. Bommer, G., AltenÄhr, E., Kühnau, J., Klöppel, G.: Ultrastructure of hemangiopericytoma associated with Paraneoplastic Hypoglycemia. Z. Krebsforsch. 85, 231–241 (1976)

  4. Braun, P., Ducharme, J.S., Davignon, A.: Hémangiomatose hépatique du nourisson: Diagnostic et traitment. Helv. Paediat. Acta. 30, 159–167 (1975)

  5. Bruns, R.R., Palade, G.E.: Studies on blood capillaries. J. Cell. Biol. 37, 244–276 (1968)

  6. Danz, M., Katenkamp, D. Katenkamp, D., Ruffert, K.: Zur Frage der morphologischen Differentialdiagnose von HÄmangioendotheliom und HÄmangiosarkom. Zbl. allg. Path. 113, 331–342 (1970)

  7. Dehner, L.P., Ishak, K.G.: Vascular tumors of the liver in infants and children. A study of 30 cases and review of the literature. Arch. Path. 92, 101–111 (1971)

  8. Fuchs, U.: Die feinmikroskopische Struktur des KapillÄren HÄmangioma des Menschen. Beitr. path. Anat. 135, 309–321 (1967)

  9. Haustein, U.F., Klug, H.: Zur Ultrastruktur der Hautkapillaren bei Lupus Erythematodes, Dermatomyositis und Progressiver Sklerodermie. Derm. Mschr. 161, 353–363 (1975)

  10. Laird, W.P., Friedman, S., Koop, C.E., Schwartz, G.J.: Hepatic hemangiomatosis. Successful management by hepatic artery ligation. Am. J. Dis. Child. 130, 657–659 (1976)

  11. Ludwig, J., Hoffmann, H.N.: Hemangiosarcoma of the liver. Spectrum of morphologic changes and clinical findings. Mayo Clinic Proc. 50, 255–263 (1975)

  12. McLean, R.H., Moller, J.H., Walwick, W.J., Satran, L., Lucas, R.V.: Multinodular haemangiomatosis of the liver in infancy. Pediatrics. 49, 563–573 (1972)

  13. Murad, T.M., Von Haam, E., Murthy, M.S.W.: Ultrastructure of a haemangiopericytoma and a glomus tumor. Cancer 22, 1239–1249 (1968)

  14. Ramsey, H.J.: Fine structure of hemangiopericytoma and hemangioendothelioma. Cancer. 19, 2005–2018 (1966)

  15. Rocchini, A.P., Rosenthal, A., Issenberg, H.J., Madas, A.S.: Hepatic Hemangioendothelioma: Haemodynamic observations and treatment. Pediatrics. 57, 131–136 (1976)

  16. Schiliro, G., Guarneri, B., Russo, A.: A case of multiple neonatal haemangiomatosis with favourable outcome following steroid therapy. Acta Paediatr. Scand. 65, 267–270 (1976)

  17. Schoefl, G.I.: Studies on inflammation. III. Growing capillaries: Their structure and permeability. Virch. Arch. path. Anat. 337, 97–141 (1963)

  18. Silverberg, S.G., Willson, M.A., Board, J.A.: Hemangiopericytoma of the uterus: An ultrastructural study. Amer. J. Obstet. Gynec. 110, 397–404 (1971)

  19. Simon, G.: über die Struktur der Kapillarwand. Elektronenmikroskopische Untersuchungen. Münch. med. Wschr. 108, 1281–1287 (1966)

  20. Stehbens, W.E., Ludatscher, R.M.: Fine structure of senile angiomas of human skin. Angiology. 19, 581–592 (1968)

  21. Steiner, G.C., Dorman, H.D.: Ultrastructure of hemangio-endothelial sarcoma of bone. Cancer. 29, 122–135 (1972)

  22. Stiller, D., Katenkamp, D., Küttner, K.: Cellular Differentiations and Structural Characteristics in Nasopharyngeal Angiofibromas. An Electron-Microscopic Study. Virch. Arch. A. Path. Anat. Histol. 371, 273–282 (1976)

  23. Touloukian, R.J.: Hepatic haemangioendothelioma during infancy: pathology, diagnosis and treatment with predinsone. Pediatrics. 45, 71–76 (1970)

  24. Weibel, E.R., Palade, G.E.: New cytoplasmic components in arterial endothelia. J. Cell. Biol. 23, 101–103 (1964)

  25. Willis, R.A.: Pathology of Tumours. 5th ed. p. 726. London: Butterworths 1967

  26. Zarem, H.A., Edgerton, M.T.: Induced resolution of cavernous hemangiomas following prednisolone therapy. Plast. Reconstr. Surg. 39, 76–83 (1967)

  27. Zweifach, D.W.: The influence of the adrenal cortex on behaviour of the terminal vascular bed. Ann. N.Y. Acad. Sci. 56, 626–630 (1953)

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Balázs, M., Denes, J. & Lukács, V.F. Fine structure of multiple neonatal haemangioendothelioma of the liver. Virchows Arch. A Path. Anat. and Histol. 379, 157–168 (1978). https://doi.org/10.1007/BF00432485

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Key words

  • Endothelial cells
  • Pericytes
  • Basement membrane
  • Reticular fibres