Virchows Archiv A

, Volume 373, Issue 3, pp 267–278 | Cite as

Muscle changes in rheumatoid arthritis

A review of the literature with a study of 100 cases
  • éva Magyar
  • A. Talerman
  • Judith Mohácsy
  • H. W. Wouters
  • W. C. de Bruijn
Article

Summary

Muscle changes were studied in biopsy material obtained from 100 patients suffering from classical rheumatoid arthritis. The abnormalities consisted of denervation atrophy of type II muscle fibres, degenerative changes in the sarcoplasm including presence of nemaline rods, and changes within the interstitium: namely perivascular nodular myositis, lymphocytic accumulations, different stages of vasculitis and abnormalities within the intramuscular nerves and muscle spindles. The muscles examined were always severely affected. It is considered that the simultaneous presence of these abnormalities is suggestive of rheumatoid arthritis. The importance of histochemical studies is emphasized. The literature concerning muscle changes in rheumatoid arthritis is reviewed.

Key words

Rheumatoid arthritis Muscle changes 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adams, R.D.: Nemaline rod myopathy. In: Disease of muscle. 3d ed., p. 247. New York: Harper and Row Publishers 1975Google Scholar
  2. Beneke, G.: Die Reaktion des Muskelbindegewebes bei rheumatischen Erkrankungen. Verh. Dtsch. Ges. Rheumat. 2, 142–163 (1972)Google Scholar
  3. Bethlem, J.: Muscle pathology. Amsterdam-London: North-Holland Publishing Company 1970Google Scholar
  4. Cape, C.A., Johnson, W.W., Pitner, S.E.: Nemaline structures in polymyositis. Neurology (Minneap.) 20, 494–502 (1970)Google Scholar
  5. Chamberlain, M.A., Bruckner, F.E.: Rheumatoid neuropathy: Clinical and electrophysiological features. Ann. rheum. Dis. 29, 609–616 (1970)Google Scholar
  6. Cruickshank, B.: The arteritis in rheumatoid arthritis. Ann. rheum. Dis. 13, 136–146 (1954)Google Scholar
  7. Curtis, A.C., Pollard, H.M.: Felty's syndrome: its several features including tissue changes, compared with other forms of rheumatoid arthritis. Ann. intern. Med. 13, 2265–2284 (1940)Google Scholar
  8. De Forest, G.K., Bunting, H., Kenney, W.E.: Rheumatoid arthritis: The diagnostic significance of focal cellular accumulations in skeletal muscles. Amer. J. Med. 2, 40–44 (1947)Google Scholar
  9. Engel, A.G.: Late-onset rod myopathy (a new syndrome?): Light and electron microscopic observations in two cases. Proc. Mayo Clin. 41, 713–741 (1966)Google Scholar
  10. Engel, W.K.: A critique of congenital myopathies and other disorders. In: Milhorat, A.T. (ed.), Exploratory concepts in muscular dystrophy and related disorders, pp. 27–40. Amsterdam: Philadelphia: Lea and Febiger 1966Google Scholar
  11. Fassbender, H.G.: Pathologie und Pathogenese der GefÄ\prozesse bei chronischer Polyarthritis. Verh. Dtsch. Ges. Rheumat. 4, 306–310 (1976)Google Scholar
  12. Hartmann, F.: Differenzierung der chronischen Polyarthritis. Z. Rheumaforsch. 24, 161–179 (1965)Google Scholar
  13. Haslock, D.I., Wright, V., Harriman, D.G.F.: Neuromuscular disorders in rheumatoid arthritis: A motorpoint muscle biopsy study. Quart. J. Med. 39, 335–358 (1970)Google Scholar
  14. Hollander, L.J.: Arthritis and allied conditions. A textbook of rheumatology, 7th ed., p. 196. Philadelphia: Lea and Febiger 1966Google Scholar
  15. Jerusalem, F., Goetze, H., Mumenthaler, M.: Zur diagnostischen SpezifizitÄt von nemaline Strukturen. Z. Neurol. 200, 148–157 (1971)Google Scholar
  16. Kulka, J.P.: Vascular derangement in rheumatoid arthritis. In: Modern trends in rheumatology, 1st ed., pp. 49–69, edit. by Hill, A.G.S. London: Butterworth 1966Google Scholar
  17. Magyar, é., Talerman, A., Fehér, M., Wouters, H.W.: Plasma cell myositis in rheumatoid arthritis. Acta med. Acad. Sci. hung. 31, 95–98 (1974)Google Scholar
  18. Magyar, é., Talerman, A., Wouters, H.W.: Histological abnormalities in the muscle spindles in rheumatoid arthritis. Ann. rheum. Dis. 32, 143–150 (1973)Google Scholar
  19. Morrison, L.R., Short, C.L., Ludwig, A.O., Schwab, R.S.: The neuromuscular system in rheumatoid arthritis. Amer. J. med. Sci. 214, 33–49 (1947)Google Scholar
  20. Paget, J.: The clinical methods on the nervous mimicry of organic diseases. Lancet 1873 II, 727–729Google Scholar
  21. Radnai, B.: Vascular changes in peripheral nerves and skeletal muscles in rheumatoid arthritis. Acta morph. Acad. Sci. hung. 3, 87–100 (1953)Google Scholar
  22. Radnai, B.: Comparative morphology of small vessel lesions in rheumatoid arthritis and periarteritis nodosa. Acta morph. Acad. Sci. hung. 17, 69–79 (1969)Google Scholar
  23. Rewcastle, N.B., Humphrey, J.G.: Vacuolar myopathy. Arch. Neurol. (Chic.) 12, 570–582 (1965)Google Scholar
  24. Ropes, M.W., Bennet, G.A., Cobbs, S., Jacox, R., Jessar, R.A.: Revision of diagnostic criteria for rheumatoid arthritis. Bull. rheum. Dis. 9, 175–176 (1958)Google Scholar
  25. Sokoloff, D., Wilens, S.L., Bunim, J.J., McEwen, C.: Diagnostic value of histological lesions of striated muscle in rheumatoid arthritis. Amer. J. med. Sci. 219, 174–182 (1950)Google Scholar
  26. Steiner, G., Freund, H.A., Leichtentritt, B., Maun, M.E.: Lesions of skeletal muscles in rheumatoid arthritis (nodular polymyositis). Amer. J. Path. 22, 103–145 (1946)Google Scholar
  27. Yates, D.A.: Muscular changes in rheumatoid arthritis. Ann. rheum. Dis. 22, 342–347 (1963)Google Scholar

Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • éva Magyar
    • 1
  • A. Talerman
    • 3
  • Judith Mohácsy
    • 2
  • H. W. Wouters
    • 3
  • W. C. de Bruijn
    • 4
  1. 1.Department of PathologyPostgraduate Medical SchoolBudapestHungary
  2. 2.2nd Department of PathologySemmelweis Medical SchoolBudapestHungary
  3. 3.Department of Pathology and Department of Orthopaedic SurgeryDr. Daniel den Hoed KliniekRotterdamHolland
  4. 4.Department of PathologyErasmus UniversityRotterdamHolland

Personalised recommendations