Advertisement

Virchows Archiv A

, Volume 362, Issue 3, pp 195–205 | Cite as

Ultrastructural study of the thyroid in adult hypothyroidism

  • Paule Ketelbant -Balasse
  • Pierre Nève
Article

Summary

The ultrastructural aspect of the thyroid in acquired hypothyroidism in adult human is quite similar to that described in chronic autoimmune thyroiditis. Only a few follicles persist: most of their cells show an oncocytic transformation. Rare colloid cells are present. A new thyroid cell type characterized by numerous cytoplasmic fibrils is described and its ultimobranchial origin is discussed.

Keywords

Public Health Fibril Hypothyroidism Thyroiditis Ultrastructural Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bargmann, W.: Der Feinbau der Schildrüse. In: Handbuch der mikroskopischen Anatomie des Menschen, Bd. 6, Heft 2, S. 25–95. Berlin: Springer 1939Google Scholar
  2. Bastenie, P. A.: Inflammations chroniques et sléroses du corps thyroϊde. Arch. int. Méd. exp. 12, 1–170 (1937)Google Scholar
  3. Bastenie, P. A., Bonnyns, M., Vanhaelst, L.: Thyroiditis and acquired hypothyroidism in adults. In: Thyroiditis and thyroid function (P. A. Bastenie, A. M. Ermans, eds.), p. 211–228. Oxford: Pergamon Press 1972Google Scholar
  4. Bastenie, P. A.: Ermans, A. M.: Thyroiditis and thyroid function. Clinical, morphological and physiopathological studies. Pergamon Press, 1972. International Series of Monographs in pure and applied biology, vol. 36Google Scholar
  5. Binet, J., De Gennes, J. L., Decourt, J.: Etude cytologique au microscope électronique de l'infiltration lymphoplasmocytaire dans deux cas de thyroïdite d'Hashimoto. Rev. franç. Etud. clin. biol. 9, 1011 (1963)Google Scholar
  6. Brandes, D., Anton, E., Orbegoso, C. M.: Hashimoto's thyroiditis. Ultrastructure and histochemistry of the cellular infiltrate. Johns Hopkins med. J. 124, 211–223 (1969)Google Scholar
  7. Braunstein, H., Stephens, C. L.: Parafollicular cells of human thyroid. Arch. Path. 86, 659–666 (1968)Google Scholar
  8. Calvert, R.: Transitional cells in the postnatal tlryroid gland of the rat. Anat. Rec. 174, 341–360 (1972)Google Scholar
  9. Hamperl, H.: Oncocytes and the so-called Hürthle cell tumor. Arch. Path. 49, 563–567 (1950)Google Scholar
  10. Harcourt-Webster, J. N., Stott, N. C. H.: Histochemical study of oxidative and hydrolytic enzymes in the human thyroid. J. Path. Bact. 92, 291–302 (1966)Google Scholar
  11. Harris, M.: The cellular infiltrate in Hashimoto's disease and focal lymphocytic thyroiditis. J. clin. Path. 22, 326 (1969)Google Scholar
  12. Heimann, P.: Ultrastructure of human thyroid. Acta endocr. (Kbh) Suppl. 110, 1–102 (1966)Google Scholar
  13. Hübner, G., Paulissen, F., Kleinsasser, O.: Zur Feinstruktur und Genese der Onkocyten. Virchows Arch. path. Anat. 343, 34–50 (1967)Google Scholar
  14. Hürthle, K.: Beiträge zur Kenntnis des Secretionsvorgangs in der Schilddrüse. Pflügers Arch. ges. Physiol. 56, 1–44 (1894)Google Scholar
  15. Irvine, W. J., Muir, A. R.: An electron microscopic study of Hashimoto thyroiditis. Quart. J. exp. Physiol. 48, 13–26 (1963)Google Scholar
  16. Jaffé, R. H.: Fat contents of pathologic thyroids in man. Histologic studies. Arch. intern. Med. 5, 13–22 (1928)Google Scholar
  17. Ketelbant-Balasse, P., Rodesch, F., Nève, P., Pasteels, J. M.: Scanning electron microscope observations of apical surfaces of dog thyroid cells. Exp. Cell Res. 79, 111–119 (1973)Google Scholar
  18. Klinck, G. H., Oertel, J. E., Winship, T.: Ultrastructure of normal human thyroid. Lab. Invest. 22, 2–22 (1970)Google Scholar
  19. Luft, J.: Improvements in epoxy embedding methods. J. Cell Biol. 9, 409–414 (1961)Google Scholar
  20. Nève, P.: Ultrastructure des cellules folliculaires d'une thyroïde humaine normale. J. Microscopie 4, 811–814 (1965)Google Scholar
  21. Nève, P.: The ultrastructure of the thyroid in a case of Hashimoto goitre (struma lymphomatosa). Path. europ. 1, 234–245 (1966)Google Scholar
  22. Nève, P.: The ultrastructure of thyroid in chronic autoimmune thyroiditis. Virchows Arch. Abt. A 346, 302–317 (1969)Google Scholar
  23. Nève, P.: Ultrastructure of the thyroid in De Quervain's subacute granulomatous thyroiditis. Virchows Arch. Abt. A 351, 87–98 (1970)Google Scholar
  24. Nève, P., Dumont, J. E.: Time sequence of ultrastructural changes in the stimulated dog thyroid. Z. Zellforsch. 103, 61–74 (1970)Google Scholar
  25. Nève, P., Eagleton, B. G., Wollman, S. H.: Fine structure of colloid cells in the thyroid gland. J. clin. Endocr. 31, 38–42 (1970)Google Scholar
  26. Nève, P., Wollman, S. H.: Fine structure of ultimobranchial follicles in the thyroid gland of the rat. Anat. Rec. 171, 259–272 (1971)Google Scholar
  27. Reidbord, H. E., Fisher, E. R.: Ultrastructural features of subacute granulomatous thyroiditis and Hashimoto's disease. Amer. J. clin. Path. 59, 327–337 (1973)Google Scholar
  28. Reynolds, E. S.: The use of lead citrate at high pH as electron opaque stain in electron microscopy. J. Cell Biol. 17, 208–213 (1963)Google Scholar
  29. Seljelid, R.: Endocytosis in thyroid cell. II. A microinjection study of the origin of colloid droplets. J. Ultrastr. Res. 17, 40–420 (1967)Google Scholar
  30. Sugiyama, S.: Histological studies of the human thyroid gland observed from the viewpoint of its postnatal development. Ergebn. Anat. Entwickl.-Gesch. 39, 1–71 (1967)Google Scholar
  31. Teitelbaum, S. L., Shieber, W., Moore, K. E.: Ultrastructural studies of the parafollicular cells of dog and human thyroid. J. Cell Biol. 27, 210a (1970)Google Scholar
  32. Tremblay, C., Pearse, A. C. E.: Histochemistry of oxidative enzymes systems in the human thyroid, with special reference to Askanazy cells. J. Path. Bact. 80, 353–358 (1960)Google Scholar
  33. Vandyke, J. H.: Behavior of ultimobranchial tissue in the post-natal thyroid gland: the origin of thyroid cystoadenomata in the rat. Anat. Rec. 88, 369–391 (1944)Google Scholar
  34. Vandyke, J. H.: Behavior of ultimobranchial tissue in the post-natal thyroid gland: epithelial cysts, their relation to thyroid parenchyma and to “new growths” in the thyroid gland of young sheeps. Amer. J. Anat. 76, 201–251 (1945)Google Scholar
  35. Vandyke, J. H.: The ultimobranchial body. In: Comparative endocrinology (A. Gorbman, ed.), p. 320–339. New York: John Wiley & Sons, 1959Google Scholar
  36. Wetzel, B. K., Wollman, S. H.: Fine structure of second kind of thyroid follicle in the C3H mouse. Endocrinology 84, 563–578 (1969)Google Scholar
  37. Wollman, S. H., Nève, P.: Ultimobranchial follicles in the thyroid glands of rats and mice. Recent Progr. Hormone Res. 27, 213–234 (1971)Google Scholar

Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • Paule Ketelbant -Balasse
    • 1
  • Pierre Nève
    • 1
  1. 1.Laboratories of Electron Microscopy, Pathology and Experimental Medicine, Faculty of MedicineUniversité Libre de BruxellesBrusselsBelgium

Personalised recommendations