, Volume 75, Issue 2, pp 210–211 | Cite as

Nonspecific excitatory effects of morphine: Reverse-order precipitated withdrawal and dose-dose interactions

  • D. R. Stevens
  • W. R. Klemm
Short Reports


We recently reported that, in naive mice pretreated with naloxone, morphine can cause withdrawal-like signs that seemingly are not mediated by “opiate” receptors. Such results were confirmed and extended here with another mouse strain. Repetitive vertical jumping could occur irrespective of injection sequence and depended on dose and dose ratio of the two drugs.

Key words

Morphine Naloxone Mice Withdrawal Excitation Jumping 


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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • D. R. Stevens
    • 1
  • W. R. Klemm
    • 1
  1. 1.Departments of Veterinary Anatomy and Veterinary Small Animal Medicine and SurgeryTexas A & M UniversityCollege StationUSA

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