Effect of single oral doses of various neuroleptic drugs on salivary secretion rate, pH, and buffer capacity in healthy subjects
Original Investigations
Received:
- 34 Downloads
- 5 Citations
Abstract
The effects of melperone, thioridazine, levomepromazine, and chlorprotixene on salivary secretion rate, pH, and buffer capacity was studied in eight healthy volunteers given single oral doses of placebo or 10, 25, and 50 mg of the drugs in a single-blind crossover design. Both resting and stimulated saliva samples were collected before and every hour for 6 h after administration. All drugs reduced secretion rate and lowered pH and buffer capacity, mostly in a dose-dependent manner. The effects of levomepromazine and chlorprotixene were more pronounced than those of melperone and thioridazine.
Key words
Neuroleptics Salivary secretion rate Salivary pH Salivary buffer capacityPreview
Unable to display preview. Download preview PDF.
References
- Aldous JA (1964) Induced xerostomia and its relation to dental caries. J Dent Child 31:160–162Google Scholar
- Bahn SL (1972) Drug-related dental destruction. Oral Surg 33:49–54Google Scholar
- Bertram U (1967) Xerostomia: Clinical aspects, pathology and pathogenesis. Thesis. Acta Odontol Scand 25:Suppl 49:1–126Google Scholar
- Bertram U, Kragh-Sørensen P, Rafaelsen OJ, Larsen NE (1979) Saliva secretion following long-term antidepressant treatment with nortriptylin controlled by plasma level. Scand J Dent Res 87:58–64Google Scholar
- Blackwell B, Stefopoulos A, Enders P, Kuzma R, Adolphe A (1978) Anticholinergic activity of two tricyclic antidepressants. Am J Psychiatry 135:722–724Google Scholar
- Dreizen S, Brown LR (1976) Xerostomia and dental caries. In: Microbial aspects of dental caries. Proceedings Microbiol Aspects of Dental Caries, Eds Stiles, Loesche and O'Brien. Microbiol Abstr 1:263–273Google Scholar
- Ericsson Y (1959) Clinical investigations of the salivary buffering action. Acta Odontol Scand 17:131–165Google Scholar
- Ericsson Y, Hardwich L (1978) Individual diagnosis, prognosis and counselling for caries prevention. Caries Res 12:94–102Google Scholar
- Fann WE, Shannon IL (1978) A treatment for dry mouth in psychiatric patients. Am J Psychiatry 135:251–252Google Scholar
- Hostetler RM, Petersson GR, Blackwell B, Kuzma R, Adolphe A (1978) Anticholinergic activity of 5 tricyclic antidepressants in normal volunteers. Pharmacologist 20:171Google Scholar
- Jacobsson L, Glitterstam K, Palm U (1974) Objective assessment of anticholinergic side effects of tricyclic antidepressants. Acta Psychiatr Scand (Suppl) 255:47–53Google Scholar
- Pollack B, Buck IF, Kalnius L (1964) An oral syndrome complicating psychopharmacotherapy: Study II. Am J Psychiatry 121:384–386Google Scholar
- Scopp IW, Heyman RA, Goldberg MA, Croy DJ (1965) Dryness of the mouth with use of tranquilizers: Chlorpromazine. J Am Dent Assoc 71:66–69Google Scholar
- Sheth UK, Paul T, Desai NK, Pispati PK (1979) Comparative effects of cinipramine and dothiepin on salivary rate in normal volunteers. Br J Pharmacol 8:475–478Google Scholar
- Stevens JB, Wilkinson EG (1971) Drugs, dry mouth and dental disease. Psychosomatics 12:310–311Google Scholar
- Winer JA, Bahn S (1967) Loss of teeth with antidepressant drug therapy. Arch Gen Psychiatry 16:239–240Google Scholar
Copyright information
© Springer-Verlag 1981