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Psychopharmacology

, Volume 68, Issue 2, pp 155–158 | Cite as

Hallucinogenic agents as discriminative stimuli: A correlation with serotonin receptor affinities

  • Richard A. Glennon
  • Richard Young
  • John A. Rosecrans
  • Mary J. Kallman
Original Investigations

Abstract

A choice between two levers in an operant chamber was used to train 24 rats, under a variable-interval 15 s schedule of sweetened milk reinforcement, to discriminate a hallucinogenic (psychotomimetic) agent, 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT), from saline administration. The 5-OMe DMT stimulus generalized in a dose-related manner to each of 14 tryptamine related analogs. With the exception of one compound, the effective dose for the 5-OMe DMT response correlated highly (r=-0.86) with 5-HT receptor affinity (as determined using an isolated rat fundus preparation).

Key words

Hallucinogens Discriminative stimulus Serotonin receptor affinities 5-OMe DMT Tryptamines 

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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Richard A. Glennon
    • 1
  • Richard Young
    • 1
  • John A. Rosecrans
    • 2
  • Mary J. Kallman
    • 2
  1. 1.Department of Pharmaceutical Chemistry School of PharmacyVirginia Commonwealth UniversityRichmondUSA
  2. 2.Department of Pharmacology, Medical College of VirginiaVirginia Commonwealth UniversityRichmondUSA

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