, Volume 66, Issue 1, pp 19–22 | Cite as

Effects of propoxyphene, ethoheptazine, and azabicyclane on schedule-controlled responding: Attenuation by pentobarbital but not naloxone

  • J. David Leander
Original Investigations


The effects of propoxyphene, ethoheptazine, and azabicyclane, alone and in combination with 1 mg/kg naloxone, were studied in pigeons responding under a multiple fixed ratio, fixed interval schedule of food presentation. Low doses of pentobarbital (3, 5.6, and 10 mg/kg) attenuated the rate-decreasing effects produced by 20 mg/kg propoxyphene, ethoheptazine, and azabicyclane. Naloxone antagonized the rate-decreasing effects produced by 10 mg/kg azabicyclane but did not antagonize the rate-decreasing effects of propoxyphene or ethoheptazine.

Key words

Propoxyphene Ethoheptazine Azabicyclane Naloxone Pentobarbital Schedule-controlled responding 


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  1. Downs, D. A., Woods, J. H.: Morphine, pentazocine and naloxone effects on responding under a multiple schedule of reinforcement in rhesus monkeys and pigeons. J. Pharmacol. Exp. Ther. 196, 298–306 (1976)Google Scholar
  2. Dykstra, L. A., Wharton, W., McMillan, D. E.: Antagonism of estonitazene's effects in rats and pigeons. Pharmacol. Biochem. Behav. 6, 215–219 (1977)Google Scholar
  3. Ferster, C. B., Skinner, B. F.: Schedules of reinforcement. New York: Appleton-Century-Crofts 1957Google Scholar
  4. Fiut, R. E., Picchioni, A. C., Chin, L.: Antagonism of convulsive and lethal effects induced by propoxyphene. J. Pharm. Sci. 55, 1085–1087 (1966)Google Scholar
  5. Fraser, H. F., Isbell, H.: Pharmacology and addiction liability of dl-and d-propoxyphene. Bull. Narc. 12, 9–14 1960Google Scholar
  6. Goldberg, S. R., Morse, W. H., Goldberg, D. M.: Some behavioral effects of morphine, naloxone and nalorphine in the squirrel monkey and the pigeon. J. Pharmacol. Exp. Ther. 196, 625–636 (1976)Google Scholar
  7. Kobayashi, S., Hasegawa, K., Oshima, T., Takagi, H.: The pharmacology of azabicyclane, a new analgesic agent. Toxicol. Appl. Pharmacol. 17, 344–354 (1970)Google Scholar
  8. Leander, J. D.: Comparing the effects of anileridine, alphaprodine and fentanyl on schedule-controlled responding by pigeons. J. Pharmacol. Exp. Ther. 206, 624–635 (1978a)Google Scholar
  9. Leander, J. D.: An analysis of normeperidine's contribution to the rate-decreasing effects of meperidine. Pharmacol. Biochem. Behav. 9, 191–194 (1978b)Google Scholar
  10. Leander, J. D.: Attenuating the rate-decreasing effects of phenylpiperidine analgesics by pentobarbital. Psychopharmacology, in press (1979)Google Scholar
  11. Leander, J. D., McMillan, D. E.: Meperidine effects of schedule-controlled responding. J. Pharmacol. Exp. Ther. 201, 434–443 (1977)Google Scholar
  12. McMillan, D. E.: Interactions between naloxone and chlorpromazine on behavior under schedule control. Psychopharmacologia 19, 128–133 (1971)Google Scholar
  13. McMillan, D. E.: Nacrotic antagonists: Advances in biochemical psychopharmacology, vol. 8, M. C. Graude, L. S. Harris, E. L. Way, J. P. Smith, J. E. Villarreal, eds. New York: Raven 1974Google Scholar
  14. McMillan, D. E., Leander, J. E.: Interactions between naloxone and narcotic analgesics under three schedules that induce polydipsia. Pharmacol. Biochem. Behav. 5, 195–200 (1976)Google Scholar
  15. McMillan, D. E., Wolfe, P. S., Carchman, R. A.: Antagonism of the behavioral effects of morphine and methadone by narcotic antagonists in the pigeon. J. Pharmacol. Exp. Ther. 175, 443–458 (1970)Google Scholar
  16. Seifter, J., Eckfeld, D. K., Letchack, I., Gore, E. M., Glassman, J. M.: Pharmacological properties of some azacycloheptane analgesics. Fed. Proc. 13, 403 (1954)Google Scholar
  17. Soloway, A. H.: Analgesics, In: Principles of medicinal chemistry, W. O. Foye, ed., pp. 252–274. Philadelphia: Lea and Febiger 1974Google Scholar
  18. Wang, R. I. H.: A controlled clinical comparison of the analgesic efficacy of ethoheptazine, propoxyphene, and placebo. Eur. J. Clin. Pharmacol. 7, 183–185 (1974)Google Scholar
  19. Winter, L., Jr., Calman, H. I., Caruso, W. A., Post, A.: A double-blind comparison of ethoheptazine citrate, propoxyphene hydrochloride, and placebo. Curr. Ther. Res. 15, 383–390 (1973)Google Scholar

Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • J. David Leander
    • 1
  1. 1.Department of Pharmacology, School of Medicine, 231HUniversity of North CarolinaChapel HillUSA

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