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Activating and anesthetic effects of general depressants

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Abstract

The long-sleep (LS) and short-sleep (SS) lines of mice were derived by selective breeding with respect to ethanol sleep time. We found that in current generations LS mice also have longer sleep times than SS mice to trichloroethanol and paraldehyde. Two subsequent experiments tested our hypothesis that mice that are relatively insensitive to the hypnotic effects of depressant drugs might be relatively activated by low doses of these drugs. Both experiments failed to support the hypothesis. First, although SS mice were more activated than LS mice by subhypnotic doses of paraldehyde, the lines did not differ in the degree of activation produced by low doses of trichloroethanol. Second, among mice from a genetically heterogeneous population (HS), there was no relation between the degree of activation induced by a low dose of ethanol and sensitivity to the hypnotic effects of a higher dose.

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References

  1. DeFries, J. C., Hegmann, J. P., Ross, D. B., Howard, M. K.: A quantitative genetic analysis of change in open-field behavior of mice. Psychon. Sci. 17, 153–154 (1969)

  2. Dolce, G., Decker, H.: The effects of ethanol on cortical and subcortical electrical activity in cats. Res. Commun. Chem. Pathol. Pharmacol. 3, 523 (1972)

  3. Erwin, V. G., Heston, W. D. W., McClearn, G. E., Deitrich, R. A.: Effect of hypnotics on mice genetically selected for sensitivity to ethanol. Pharmacol. Biochem. Behav. 4, 679–683 (1976)

  4. Heston, W. D. W., Erwin, V. G., Anderson, S. M., Robbins, H. A.: A comparison of the effects of alcohol on mice selectively bred for difference in ethanol sleep time. Life Sci. 14, 365–370 (1974)

  5. McClearn, G. E., Kakihana, R.: Selective breeding for ethanol sensitivity in mice. Behav. Genet. 3, 409–410 (1973)

  6. McClearn, G. E., Wilson, J. R., Meredith, W.: The use of isogenic and heterogenic mouse stocks in behavioral research. In: Contributions to behavior-genetic analysis: the mouse as a prototype (Lindzey and Thiessen, eds.), pp. 3–22. New York: Appleton-Century-Crofts 1970

  7. Murphree, H. B.: Electroencephalographic and other evidence for mixed depressant and stimulant actions of alcoholic beverages. Ann. N. Y. Acad. Sci. 215, 325 (1973)

  8. Read, G. W., Cutting, W., Furst, A.: Comparison of excited phases after sedatives and tranquilizers. Psychopharmacologia (Berl.) 1, 346–350 (1960)

  9. Ritchie, J. M.: The aliphatic alcohols. In: The pharmacological basis of therapeutics, 4th ed. (Goodman and Gilman, eds.), pp. 135–150. New York: Macmillan 1970

  10. Sanders, B.: Sensitivity to low doses of ethanol and pentobarbital in mice selected for sensitivity to hypnotic doses of ethanol. J. Comp. Physiol. Psychol. 90, 394–398 (1976)

  11. Siemens, A. J., Chan, A. W. K.: Differential effects of pentobarbital and ethanol in mice. Life Sci. 19, 581–589 (1976)

  12. Waldeck, B.: Ethanol and caffeine: a complex interaction with respect to locomotor activity and central catecholamines. Psychopharmacologia (Berl.) 36, 209–220 (1974)

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Sanders, B., Sharpless, S.K., Collins, A.C. et al. Activating and anesthetic effects of general depressants. Psychopharmacology 56, 185–189 (1978). https://doi.org/10.1007/BF00431847

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Key words

  • Depressant drugs
  • Alcohol
  • Genetic differences