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Psychopharmacology

, Volume 56, Issue 2, pp 115–117 | Cite as

Effects of piracetam on regional cerebral blood flow and mental functions in patients with organic dementia

  • Lars Gustafson
  • Jarl Risberg
  • Margareth Johanson
  • Margareta Fransson
  • V. Alexander Maximilian
Article

Abstract

The effects of piracetam (Nootropil®, UCB 6215) on mental functions and on regional cerebral blood flow (rCBF) were investigated in eight patients in the presenile age who displayed symptoms of moderate dementia. The double-blind crossover design included nine measurement occasions, each involving rCBF measurement by the 133-Xe inhalation method, ratings of symptoms of dementia, personality changes, and side effects, and a psychometric investigation. Three investigations were included in each of three treatment periods. The first investigation in a period was made without medication. Then either placebo or piracetam 4.8 g/day or 9.6 g/day was given during four weeks with measurements after 2 weeks and 4 weeks. There were intervals of 4 weeks without medication between the treatment periods. Piracetam had no significant effect on either mental functions or rCBF.

Key words

Piracetam Mental functions Presenile dementia Regional cerebral blood flow 133-Xe Inhalation method 

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Lars Gustafson
    • 1
  • Jarl Risberg
    • 1
  • Margareth Johanson
    • 1
  • Margareta Fransson
    • 1
  • V. Alexander Maximilian
  1. 1.Laboratory of Neuropsychology, Department of PsychiatryUniversity HospitalLundSweden

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