Archives of Dermatological Research

, Volume 279, Issue 5, pp 285–292

Expression of a Hodgkin and Reed-Sternberg cell associated antigen (Ki-1) in cutaneous lymphoid infiltrates

  • E. Ralfkiaer
  • J. Bosq
  • K. C. Gatter
  • R. Schwarting
  • J. Gerdes
  • H. Stein
  • D. Y. Mason
Original Contributions

Summary

Skin biopsy specimens from normal skin and from 115 patients with benign dermatoses, pre- or pseudo-malignant disorders or malignant cutaneous lymphomas have been examined immunohistologically for expression of the Reed-Sternberg cell associated antigen CD30 detected by monoclonal antibodies Ki-1 and Ber-H2. The antibodies stained the atypical cells in lymphomatoid papulosis, a proportion of the neoplastic cells in some cases of mycosis fungoides and most of the neoplastic cells in six large cell anaplastic/pleomorphic non-Hodgkin's lymphomas. The lymphoid cells in all other specimens were Ki-1- and Ber-H2-negative. In all cases, expression of the Ki-1/Ber-H2 antigen was accompanied by expression of activation and proliferation associated markers (i. e., HLA-DR, IL-2 receptor, transferrin receptor and the Ki-67 nuclear antigen). These data indicate the value of antibodies Ki-1 and Ber-H2 in distinguishing between lymphomatoid papulosis and other types of pre- or pseudo-malignant disorders and support the view that lymphomatoid papulosis, Hodgkin's disease and some types of non-Hodgkin's lymphoma constitute a spectrum of related disorders, originated from activated lymphoid cells.

Key words

Hodgkin's disease Lymphoma Lymphomatoid papulosis 

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • E. Ralfkiaer
    • 1
    • 3
    • 2
  • J. Bosq
    • 3
  • K. C. Gatter
    • 3
  • R. Schwarting
    • 4
  • J. Gerdes
    • 4
  • H. Stein
    • 4
  • D. Y. Mason
    • 3
  1. 1.Department of Pathology, the Finsen InstituteUniversity of CopenhagenCopenhagen ØDenmark
  2. 2.Department of Dermatology, the Finsen InstituteUniversity of CopenhagenDenmark
  3. 3.Nuffield Department of Pathology, John Radcliffe HospitalUniversity of OxfordEngland
  4. 4.Department of Pathology, Klinikum SteglitzFree University of BerlinFederal Republic of Germany

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