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Food preference following acute or chronic chlordiazepoxide administration: Tolerance to an antineophobic action

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Abstract

Chlordiazepoxide (CDP) at 15 mg/kg produced two distinct actions in a food preference test firstly a general appetite-enhancing effect, and secondly an anti-neophobic effect. Following acute injection of CDP the rats changed from eating predominantly familiar food to a novel food. This may signify an anti-neophobic effect of CDP However, following 10 days of treatment with CDP, the anti-neophobic effect was abolished and the choice of familiar food was enhanced. This could be an indication of a more general appetite-enhancing effect. Hence some form of tolerance may develop to CDP's effects over 10 days of treatment which selectively abolishes anti-neophobic action whilst leaving the appetite effect further enhanced. There were no indications of tolerance developing to the actions of CDP in animals familiarized with all the test foods before the preference test was run. Hence the presence of food novelty may be critical to the observation of some form of selective tolerance.

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References

  1. Burton MJ, Cooper SJ, Posadas-Andrews A (1980) Interactions between chlordiazepoxide and food deprivation determining chonce in a foodpreference test. Br J Pharmacol 68:157–158

  2. Cannizzaro G, Nigito S, Provenzano PM, Vitikova T (1972) Modification of depressant and disinhibitory action of flurazepam during short-term treatment in the rat. Psychopharmacologia 26:172–184

  3. Cook, L, Sepinwall J (1975) A behavioral analysis of the effects and mechanisms of action of benzodiazepines In: Costa E, Greengard P (eds) Mechanism of action of benzodiazepines. Raven, New York, pp 1–28

  4. Cooper SJ (1980a) Effects of chlordiazepoxide and diazepam on feeding performance in a food-preference test. Psychopharmacology 69:73–78

  5. Cooper SJ (1980b) Benzodiazepines as appetite-enhancing compounds. Appetite 1:7–19

  6. Cooper SJ, Crummy YMT (1978) Enhanced choice of familiar food in a food preference test after chlordiazepoxide administration. Psychopharmacology 59:51–56

  7. Cooper SJ, Francis RL (1979a) Effects of acute or chronic administration of chlordiazepoxide on feeding parameters using two food textures in the rat. J Pharm Pharmacol 31:743–746

  8. Cooper SJ, Francis RL (1979b), Water intake and time course of drinking after single or repeated chlordiazepoxide injections. Psychopharmacology 65:191–195

  9. Cooper SJ, McClelland A (1980) Effects of chlordiazepoxide, food familiarization, and prior shock experience on food choice in rats. Pharmacol Biochem Behav 12:23–28

  10. Cooper SJ, Posadas-Andrews A (1980) Famiharity-induced feeding in a food-preference test: effects of chlordiazepoxide and naloxone compared with food-deprivation. Br J Pharmacol 69:273–274

  11. File SE (1979) ACTH as a mediator in anxiety. In: Saletu B, Berner P, Hollister L (eds) Neuro-psychopharmacology. Pergamon, Oxford, pp. 439–448

  12. File SE (1980) The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs. J Neurosci Methods 2:219–238

  13. File SE, Hyde JRG (1978) Can social interaction be used to measure anxiety? Br J Pharmacol 62:19–24

  14. Fletcher A, Green SE, Hodges HM (1980) Evidence for role for GABA in benzodiazepine, effects on feeding in rats. Br J Pharmacol 69:274–275

  15. Francis RL, Cooper SJ (1979) Chlordiazepoxide-induced disruption of discrimination behaviour: a signal detection analysis. Psychpharmacology 63:307–310

  16. Goldberg ME, Manian AA, Efron DE (1967) A comparative study of certain pharmacologic responses following acute and chronic administrations of chlordiazepoxide. Life Sci 6:481–491

  17. Margules DL, Stein L (1968) Increase of ‘antianxiety’ activity and tolerance of behavioral depression during chronic administration of oxazepam. Psychopharmacologia 13:74–80

  18. Poschel BPH (1971) A simple and specific screen for benzodiazepine-like drugs. Psychopharmacologia 19:193–198

  19. Randall LO, Schallek W, Heise GA, Keith EF, Bagdon RE (1960) The psychosedative properties of methaminodiazepoxide. J Pharmacol Exp Ther 129:163–171

  20. Rolls ET, Rolls BJ (1973) Altered food preference after lesions in the basolateral region of the amygdala in the rat. J Comp Physiol Psychol 83:248–259

  21. Sansone M (1979) Effects of repeated administration of chlordiazepoxide on spontaneous locomotor activity in mice. Psychopharmacology 66:109–110

  22. Squires RF, Klepner CA, Benson DI (1980) Multiple benzodiazepine receptor complexes: some benzodiazepine recognition sites are coupled to GABA receptors and ionophores. In: Pepeu G, Kuhar MJ, Enna SJ (eds) Receptors for neurotransmitters and peptide hormones. Raven, New York, pp 285–293

  23. Sullivan AC, Cheng L (1978) Appetite regulation and its modulation by drugs. In: Hathcock JN, Coon J (eds) Nutrition and drug interrelations. Academic, New York, pp 21–82

  24. Vellucci SV, File SE (1979) Chlordiazepoxide loses its anxiolytic action with long-term treatment. Psychopharmacology 62:61–65

  25. Warner RS (1965) Management of the office patient with anxiety and depression. Psychosomatics 6:347–351

  26. Winer BJ (1971) Statistical principles in experimental design. McGraw-Hill, New York

  27. Wise RA, Dawson V (1974) Diazepam-induced eating and lever-pressing for food in sated rats. J Comp Physiol Psychol 86:930–941

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Correspondence to Steven J. Cooper.

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Cooper, S.J., Burnett, G. & Brown, K. Food preference following acute or chronic chlordiazepoxide administration: Tolerance to an antineophobic action. Psychopharmacology 73, 70–74 (1981). https://doi.org/10.1007/BF00431104

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Key words

  • Acute and chronic injections
  • Chlordiazepoxide
  • Food novelty
  • Food familiarization
  • Food preference