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Food preference following acute or chronic chlordiazepoxide administration: Tolerance to an antineophobic action

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Chlordiazepoxide (CDP) at 15 mg/kg produced two distinct actions in a food preference test firstly a general appetite-enhancing effect, and secondly an anti-neophobic effect. Following acute injection of CDP the rats changed from eating predominantly familiar food to a novel food. This may signify an anti-neophobic effect of CDP However, following 10 days of treatment with CDP, the anti-neophobic effect was abolished and the choice of familiar food was enhanced. This could be an indication of a more general appetite-enhancing effect. Hence some form of tolerance may develop to CDP's effects over 10 days of treatment which selectively abolishes anti-neophobic action whilst leaving the appetite effect further enhanced. There were no indications of tolerance developing to the actions of CDP in animals familiarized with all the test foods before the preference test was run. Hence the presence of food novelty may be critical to the observation of some form of selective tolerance.

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Correspondence to Steven J. Cooper.

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Cooper, S.J., Burnett, G. & Brown, K. Food preference following acute or chronic chlordiazepoxide administration: Tolerance to an antineophobic action. Psychopharmacology 73, 70–74 (1981).

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Key words

  • Acute and chronic injections
  • Chlordiazepoxide
  • Food novelty
  • Food familiarization
  • Food preference