Virchows Archiv A

, Volume 393, Issue 2, pp 165–181 | Cite as

Primary adenocarcinomas of the human urinary bladder: Histochemical, immunological and ultrastructural studies

  • Joseph Alroy
  • Danica Roganovic
  • Barbara F. Banner
  • Jerome B. Jacobs
  • Frederick B. Merk
  • Angelo A. Ucci
  • Paul W. L. Kwan
  • John S. CoonIV
  • Alexander W. MillerIII
Original Articles


Neoplastic and non-neoplastic tissue specimens from ten patients with primary adenocarcinoma of the urinary bladder were examined. Most of these tumors were associated with either foci of transitional cell carcinoma and/or with glandular metaplasia of the bladder epithelium. The mucin produced by the neoplastic cells was PAS, alcian blue, mucicarmine, PB/KOH/PAS, and RPB/KOH/PAS-positive. ABH isoantigens of these tumors were not always deleted. Ultrastructurally, the neoplastic cells resembled goblet cells. Their plasma membrane had numerous microvilli with prominent glycocalyx. Proliferation and attenuation of tight junctions were noted. The gap junctions were few and small. Two types of desmosomes were found. The ultrastructural features of the neoplastic cells were attributed in part to the malignant transformation and in part to the direction of their differentiation. We have not observed any distinctive morphologic, histochemical, immunologic or ultrastructural features that might be diagnostic for these adenocarcinomas.

Key words

Urinary bladder adenocarcinomas ABH isoantigens Ultrastructure 


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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • Joseph Alroy
    • 1
  • Danica Roganovic
    • 1
    • 2
  • Barbara F. Banner
    • 3
  • Jerome B. Jacobs
    • 4
  • Frederick B. Merk
    • 1
  • Angelo A. Ucci
    • 1
  • Paul W. L. Kwan
    • 1
  • John S. CoonIV
    • 3
  • Alexander W. MillerIII
    • 3
  1. 1.Department of PathologyTufts University School of Medicine and Veterinary MedicineBostonUSA
  2. 2.Institute of Pathology, Medical FacultyUniversity “Kiril i Metodij”SkopjeYugoslavia
  3. 3.Department of PathologyRush Medical CollegeChicagoUSA
  4. 4.Department of PathologySt. Vincent HospitalWorcesterUSA

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