Archives of Dermatological Research

, Volume 281, Issue 4, pp 227–230 | Cite as

Allergic contact dermatitis to Ginkgo biloba L.: relationship with urushiol

  • J. -P. Lepoittevin
  • C. Benezra
  • Y. Asakawa
Original Contributions

Summary

A Ginkgo biloba L. fruit extract was prepared and purified. Three groups of guinea pigs were sensitized to the crude extract, anacardic acids 1, and cardanols 2 respectively, using the FCAT method, and the fourth group to urushiol using the epicutaneous route. Each group was tested for reaction to the primary sensitizer and to the different main aromatic compounds isolated from Ginkgo fruits. Anacardic acids were found to be good sensitizers, while cardanols failed to induce allergic contact dermatitis (ACD). No cross-reactions were observed among the compounds tested. Ginkgolic acids 1 seem to be the main allergens of Ginkgo biloba L. and the hypothesis of a biotransformation of 1 into catechol 4 is not supported by experiment.

Key words

Ginkgo biloba L. Delayed hypersensitivity Urushiol Anacardic acids Cardanols Cardols 

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References

  1. 1.
    Becker LE, Skipworth GB (1975) Ginkgo tree dermatitis, stomatitis and proctitis. J Amer Med Assoc 231:1162Google Scholar
  2. 2.
    Birch AJ, Donovan FW (1953) Studies in relation to biosynthesis. Some possible routes to derivatives of orcinol and phloroglucinol. Aust J Chem 6:360–368Google Scholar
  3. 3.
    Itokawa H, Totsuka N, Nakahara K, Takeya K, Lepoittevin JP, Asakawa Y (1987) Antitumor principles from Ginkgo biloba L. Chem Pharm Bull (Tokyo) 35:3016–3020Google Scholar
  4. 4.
    Kiong LS, Thyman JHP (1981) Long chain phenol. Part 18. Conversion of anacardic acid into urushiol. J Chem Soc Perkin I:1942–1952Google Scholar
  5. 5.
    Mitchell JC, Rook A (1979) Plants injurious to the skin. Botanical dermatology. Greengrass, Vancouver, pp 317–318Google Scholar
  6. 6.
    Reffstrup T, Boll PM (1985) Allergic 5-alkyl and 5-alkenyl resorcinols from Philodendron species. Phytochemistry 24:2563–2565Google Scholar
  7. 7.
    Sowers S, Weary PE, Collins OD, Cawley EP (1965) Ginkgo tree dermatitis. Arch Dermatol 91:452–456Google Scholar
  8. 8.
    Still CW, Kahn M, Mitra A (1978) Rapid chromatographic technique for preparative separation with moderate resolution. J Org Chem 43:2923–2925Google Scholar
  9. 9.
    Tomb RR, Foussereau J, Sell Y (1989) Mini epidemic of contact dermatitis to ginkgo tree fruit. Contact Dermatitis 19:281–283Google Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • J. -P. Lepoittevin
    • 1
    • 2
  • C. Benezra
    • 1
  • Y. Asakawa
    • 2
  1. 1.Laboratoire de Dermatochimie associé au CNRS (UA 31)Université Louis Pasteur, Clinique Dermatologique, CHUStrasbourgFrance
  2. 2.Institute of PharmacognosyTokushima Bunri UniversityTokushimaJapan

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