Immunogenetics

, Volume 22, Issue 4, pp 309–314

Interaction between des-Tyr1-γ-endorphin and HLA class I molecules: Serological detection of an HLA-A2 subtype

  • Frans H. J. Claas
  • Jan J. van der Poel
  • Ria Castelli-Visser
  • Jos Pool
  • Chen Renbiao
  • Xu Keyu
  • Jon J. van Rood
Article

Abstract

Preincubation of lymphocytes with des-Tyr1-γ-endorphin (DTγE) inhibits the reaction between some HLA alloantisera and their corresponding antigens. One HLA-A2-specific antiserum was found which could detect a subtype of the HLA-A2 antigen on DTγE-treated lymphocytes from some donors. Comparison with the HLA-A2 subtypes as defined by a combination of cytotoxic T lymphocyte typing and biochemistry showed a complete correlation with the previously described HLA-A2.3 subtype.

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Frans H. J. Claas
    • 1
  • Jan J. van der Poel
    • 1
  • Ria Castelli-Visser
    • 1
  • Jos Pool
    • 1
  • Chen Renbiao
    • 2
  • Xu Keyu
    • 3
  • Jon J. van Rood
    • 1
  1. 1.Immunohaematology and BloodbankUniversity Medical CenterLeidenThe Netherlands
  2. 2.Shanghai Institute of ImmunologyWHO Immunogenetic Collaboration CenterPeople's Republic of China
  3. 3.Chinese Academy of Medical SciencesInstitute of DermatologyNankingPeople's Republic of China

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