Virchows Archiv A

, Volume 392, Issue 1, pp 119–126 | Cite as

Human pancreatic polypeptide (HPP) immunoreactivity in an infiltrating endocrine tumour of the papilla of vater with unusual morphology

Report of a case
  • Otto Ljungberg
  • Gunnar Järnerot
  • Peter Rolny
  • Gunnar Wickbom
Case Reports


Histological, histochemical and clinical features of an endocrine duodenal tumour situated in the papillary region were studied. The tumour had a remarkable mixed histological growth pattern, consisting of epithelial glandular structures which showed a gradual transition into a spindle-cell tumour, resembling a neurogenic tumour. The neoplasm was considered malignant since it had infiltrated into the muscular layer of the duodenal wall.

The tumour was non-argentaffin and non-argyrophil. No serotonin could be demonstrated histochemically. Immunoreactive pancreatic polypeptide (HPP) was detected by indirect immunofluorescence in the majority of tumour cells of the epithelial glandular structures, whereas areas with a spindlecell pattern were almost unreactive to the HPP-antiserum. No reaction was found with antibodies against gastrin, insulin, glucagon, vasoactive intestinal polypeptide or somatostatin.

The patient had no endocrine symptoms that could be ascribed to the production of HPP by the neoplasm. Twenty-four months postoperatively, the patient's serum HPP concentration had begun to rise, suggesting recurrence of the tumour.

Key words

Duodenal endocrine tumour Papilla of Vater HPP-immunore-active tumour cells Neurogenic component 


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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • Otto Ljungberg
    • 1
  • Gunnar Järnerot
    • 2
  • Peter Rolny
    • 2
  • Gunnar Wickbom
    • 3
  1. 1.Department of PathologyUniversity of Lund, General HospitalMalmöSweden
  2. 2.Division of Gastroenterology, Department of Internal MedicineCentral County HospitalÖrebroSweden
  3. 3.Department of SurgeryCentral County HospitalÖrebroSweden

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