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Niveaux des hydrolases pancréatiques dans le pancréas et l'intestin grêle de deux types de souris obèses présentant un hyperinsulinisme: La souris obèse-hyperglycémique (oh) de Bar Harbor et la souris Néo-Zélandaise (nzo)

Levels of pancreatic hydrolases in pancreas and small bowel of two types of obese mice with hyperinsulinism: The obese-hyperglycemic Bar-Harbor mouse (OH) and the New-Zealand mouse (NZO)

Die Spiegel der pankreatischen Hydrolasen in der Bauchspeicheldrüse und im Dünndarm bei 2 Arten von fetten Mäusen mit Hyperinsulinismus: der fettsüchtig-hyperglykämischen Bar-Harbor-Maus (OH) und der Neuseeland-Maus (NZO)


The exocrine pancreas of young obese-hyperglycaemic mice from Bar Harbor and of adult New Zealand obese mice were compared with controls from non-obese animals. The potential activities of lipase, amylase, chymotrypsinogen, trypsinogen and ribonuclease were determined in the gland, as well as the activities corresponding to the first four proteins in the small intestine. These assays indicate that in the two congenital obesities considered, the exocrine function of the pancreas is characterized by normal enzymatic levels.


Le pancréas exocrine de la souris jeune obèsehyperglycémique de Bar Harbor et celui de la souris obèse Néo-Zélandaise adulte sont comparés à ceux de souris non-obèses témoins en dosant les activités potentielles de la lipase, de l'amylase, du chymotrypsinogène, du trypsinogène et de la ribonucléase dans la glande ainsi que les activités correspondant aux 4 premières protéines dans l'intestin grêle. Il résulte des dosages que ces paramètres du pancréas exocrine sont normaux dans les deux obésités congénitales considérées.


Die Funktion des exokrinen Pankreas wurde bei jungen fettsüchtig-hyperglykämischen Bar-Harbor-Mäusen und bei erwachsenen fettsüchtigen Neuseeland-Mäusen sowie bei nicht-fettsüchtigen Kontrolltieren verglichen. Die potentiellen Aktivitäten von Lipase, Amylase, Chymotrypsinogen, Trypsinogen und Ribonuclease wurden in der Drüse bestimmt, ferner die Aktivitäten der 4 erstgenannten Eiweißkörper im Dünndarm. Aus den Resultaten geht hervor, daß die Funktion des exokrinen Pankreas bei den beiden untersuchten Fettsuchtstypen durch normale Enzymaktivitäten charakterisiert ist.



phosphore des acides désoxy- et ribonucléiques


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Khayat, M.H., Rathé, J., Vandermeers, A. et al. Niveaux des hydrolases pancréatiques dans le pancréas et l'intestin grêle de deux types de souris obèses présentant un hyperinsulinisme: La souris obèse-hyperglycémique (oh) de Bar Harbor et la souris Néo-Zélandaise (nzo). Diabetologia 4, 232–235 (1968).

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  • Spontaneous obesity
  • spontaneous diabetes
  • small intestine
  • Bar Harbor obese hyperglycaemic (OH) mice
  • New Zealand obese (NZO) mice
  • endocrine pancreas
  • hyperinsulinism
  • insulin in serum
  • exocrine pancreas
  • lipase
  • amylase
  • chymotrypsinogen and chymotrypsin
  • trypsinogen and trypsin
  • ribonuclease