, Volume 83, Issue 2, pp 166–168 | Cite as

Opposite action of m-chlorophenylpiperazine on avoidance depression induced by trazodone and pimozide in CD-1 mice

  • Jerzy Vetulani
  • Mario Sansone
  • Leokadia Baran
  • Józef Hano
Original Investigations


m-Chlorophenylpiperazine (CPP) given in doses up to 2 mg/kg did not affect conditioned avoidance responses (CAR) of CD-1 mice pre-trained in a shuttle box. It reversed the inhibitory action of trazodone (10 mg/kg) on CAR, but dose-dependently potentiated the inhibitory effect of pimozide (0.2 and 0.5 mg/kg). Apparently, dopaminergic transmission is important for the attenuating effect of CPP on CAR inhibition.

Key words

m-Chlorophenylpiperazine Trazodone Pimozide Avoidance behaviour Mice 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Caccia S, Ballabio M, Samanin R, Zanini MG, Garattini S (1981) (-)m-Chlorophenyl-piperazine, a central 5-hydroxytryptamine agonist, is a metabolite of trazodone. J Pharm Pharmacol 33:477–478Google Scholar
  2. Fuller RW, Snoddy HD, Mason NR, Owen JE (1981) Disposition and pharmacological effects of m-chlorophenylpiperazine in rats. Neuropharmacology 20:155–162Google Scholar
  3. Garattini S (1974) Biochemical studies with trazodone. A new psychoactive drug. In: Ban TA, Silvestrini B (eds) Trazodone. Modern problems in pharmacopsychiatry. Karger, Basel, 9:29–46Google Scholar
  4. Maj J, Lewandowska A (1980) Central serotoninomimetic action of phenylpiperazines. Pol J Pharmacol Pharm 32:495–504Google Scholar
  5. Maj J, Palider W, Rawlow A (1979) Trazodone, a central serotonin antagonist and agonist. J Neural Transm 44:237–248Google Scholar
  6. McElroy JF, DuPont AF, Feldman RS (1982) The effects of fenfluramine and fluoxetine on the acquisition of a conditioned avoidance response in rats. Psychopharmacology 77:356–359Google Scholar
  7. Melzacka M, Boksa J, Maj J (1979) 1-(m-chlorophenyl)piperazine: a metabolite of trazodone isolated from rat urine. J Pharm Pharmacol 31:855–856Google Scholar
  8. Niemegeers CJE, Verbruggen FJ, Janssen PAJ (1969) The influence of various neuroleptic drugs on shock avoidance responding in rats. I. Nondiscriminated Sidman avoidance procedure. Psychopharmacologia 16:161–174Google Scholar
  9. Peters DAV, Anisman H, Pappas BA (1978) Monoamines and aversively motivated behaviors. In: Anisman H, Bignami G (eds) Psychopharmacology of aversively motivated behavior. Plenum, New York, pp 257–353Google Scholar
  10. Pinder RM, Brodgen RN, Sawyer PR, Speight TM, Spencer R, Avery GS (1976) Pimozide: A review of its pharmacological properties and therapeutic uses in psychiatry. Drugs 12:1–40Google Scholar
  11. Rokosz-Pelc A, Antikiewicz-Michaluk L, Vetulani J (1980) 5-Hydroxytryptamine-like properties of m-chlorophenylpiperazine: comparison with quipazine. J Pharmacol 32:220–222Google Scholar
  12. Samanin R, Mennini T, Ferraris A, Bendotti C, Borsini F, Garattini S (1979) m-Chlorophenylpiperazine: a central serotonin agonist causing powerful anorexia in rats. Naunyn-Schmiedeberg's Arch Pharmacol 308:159–163Google Scholar
  13. Sansone M, Melzacka M, Hano J, Vetulani J (1983) Reversal of depressant action of trazodone on avoidance behaviour by its metabolite m-chlorophenylpiperazine. J Pharm Pharmacol 35:189–190Google Scholar
  14. Silvestrini B, Cioli V, Burberi S, Catanese B (1968) Pharmacological properties of AF 1161, a new psychotropic drug. Int J Neuropharmacol 7:587–599Google Scholar
  15. Vetulani J, Sansone M, Bednarczyk B, Hano J (1982) Different effects of 3-chlorophenylpiperazine on locomotor activity and acquisition of conditioned avoidance response in different strains of mice. Naunyn-Schmiedeberg's Arch Pharmacol 319:271–274Google Scholar

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Jerzy Vetulani
    • 2
  • Mario Sansone
    • 1
  • Leokadia Baran
    • 2
  • Józef Hano
    • 2
  1. 1.CNRIstituto di Psicobiologia e PsicofarmacologiaRomaItaly
  2. 2.Institute of PharmacologyPolish Academy of SciencesKrakowPoland

Personalised recommendations