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Psychopharmacology

, Volume 83, Issue 2, pp 166–168 | Cite as

Opposite action of m-chlorophenylpiperazine on avoidance depression induced by trazodone and pimozide in CD-1 mice

  • Jerzy Vetulani
  • Mario Sansone
  • Leokadia Baran
  • Józef Hano
Original Investigations

Abstract

m-Chlorophenylpiperazine (CPP) given in doses up to 2 mg/kg did not affect conditioned avoidance responses (CAR) of CD-1 mice pre-trained in a shuttle box. It reversed the inhibitory action of trazodone (10 mg/kg) on CAR, but dose-dependently potentiated the inhibitory effect of pimozide (0.2 and 0.5 mg/kg). Apparently, dopaminergic transmission is important for the attenuating effect of CPP on CAR inhibition.

Key words

m-Chlorophenylpiperazine Trazodone Pimozide Avoidance behaviour Mice 

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References

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Jerzy Vetulani
    • 2
  • Mario Sansone
    • 1
  • Leokadia Baran
    • 2
  • Józef Hano
    • 2
  1. 1.CNRIstituto di Psicobiologia e PsicofarmacologiaRomaItaly
  2. 2.Institute of PharmacologyPolish Academy of SciencesKrakowPoland

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