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Effects of d-methamphetamine on auditory and visual reaction times and detection thresholds in the baboon

Abstract

Baboons were trained in both auditory and visual reaction time procedures to release a response lever in the presence of low-intensity stimuli. By varying the stimulus intensity from trial to trial, functions relating reaction time (elapsed time from stimulus onset to lever release) to stimulus intensity were established, and detection thresholds were measured. The effects of acute, IM injections of d-methamphetamine (0.001–1.0 mg/kg) were examined on these psychophysical performance baselines. Reaction times for acoustic stimuli generally were faster for higher drug doses, whereas reaction times for visual stimuli either lengthened or shortened, depending on both drug dose and individual differences among animals. Auditory thresholds were unaffected at all drug doses studied, whereas visual thresholds were generally elevated at doses of 0.1 mg/kg and above.

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Correspondence to Robert D. Hienz.

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Hienz, R.D., Lukas, S.E. & Brady, J.V. Effects of d-methamphetamine on auditory and visual reaction times and detection thresholds in the baboon. Psychopharmacology 85, 476–482 (1985). https://doi.org/10.1007/BF00429668

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Key words

  • d-Methamphetamine
  • Reaction time
  • Auditory thresholds
  • Visual thresholds
  • Baboon