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Psychopharmacology

, Volume 85, Issue 4, pp 419–425 | Cite as

Self-administration of low-dose cocaine by rats at reduced and recovered body weight

  • Micheal Papasava
  • George Singer
Original Investigations

Abstract

Food deprivation significantly increases self-administration of cocaine in both rats and rhesus monkeys. The objective in the present investigation was to determine the effects of varying deprivational states on the level of IV low-dose (0.1 mg/kg/infusion) cocaine self-administration in rats. In the first experiment, 32 naive rats were assigned randomly to four equal-sized groups. Two groups self-administered cocaine, the other two saline over two consecutive 10-day phases. Across phase 1 all animals were free-feeding (FF), while in phase 2, one cocaine- and one saline-reinforced group were subjected to restricted feeding until they reached 80% free-feeding weight (FFW). Results showed that cocaine-reinforced responding was related inversely to body weight. In experiment 2 another 32 rats, reduced to 80% FFW, were assigned to four equal-sized groups. Two groups self-administered cocaine, the other two saline over two consecutive 10-day phases. Across phase 1 all animals were maintained at 80% FFW, while in phase 2, one cocaine- and one saline-reinforced group were abruptly food satiated. Findings showed that cocaine-reinforced responding decreased rapidly to low levels. Finally, the group of cocaine-reinforced rats maintained at 80% FFW across both phases of experiment 2 were also abruptly food satiated. Again, responding decreased rapidly to low levels.

Key words

Drug self-administration Low-dose cocaine Food deprivation Reduced body weight Rats 

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References

  1. Campbell BA, Fibiger HC (1971) Potentiation of amphetamine-induced arousal by starvation. Nature 233:424–425Google Scholar
  2. Carroll ME (1982) Rapid acquisition of oral phencyclidine self-administration in food-deprived and food-satiated rhesus monkeys: Concurrent phencyclidine and water choice. Pharmacol Biochem Behav 17:341–346Google Scholar
  3. Carroll ME (1984) Effects of pentobarbital and d-amphetamine on oral phencyclidine self-administration in rhesus monkeys. Pharmacol Biochem Behav 20:137–143Google Scholar
  4. Carroll ME, Boe IN (1982) Increased intravenous drug self-administration during deprivation of other reinforcers. Pharmacol Biochem Behav 17:563–567Google Scholar
  5. Carroll ME, Boe IN (1984) Effects of dose on increased etonitazene self-administration by rats due to food deprivation. Psychopharmacology 82:151–152Google Scholar
  6. Carroll ME, France CP, Meisch RA (1979) Food deprivation increases oral and intravenous drug intake in rats. Science 205:319–321Google Scholar
  7. Carroll ME, France CP, Meisch RA (1981) Intravenous self-administration of etonitazine, cocaine and phencyclidine in rats during food deprivation and satiation. J Pharmacol Exp Ther 217:241–247Google Scholar
  8. Carroll ME, Henningfield JE, Meisch RA (1978) Factors determining oral intake of ethanol and other drugs by rats and rhesus monkeys. Paper presented at the symposium on substance abuse: Behavioral Aspects, American Psychological Association Meeting, TorontoGoogle Scholar
  9. Carroll ME, Meisch RA (1979) Effects of food deprivation on etonitazine consumption in rats. Pharmacol Biochem Behav 10:155–159Google Scholar
  10. Carroll ME, Meisch RA (1980a) Oral phencyclidine (PCP) self-administration in rhesus monkeys: Effects of feeding conditions. J Pharmacol Exp Ther 214:339–346Google Scholar
  11. Carroll ME, Meisch RA (1980b) The effects of feeding conditions on drug-reinforced behavior: Maintenance at reduced body weight versus availability of food. Psychopharmacology 68:121–124Google Scholar
  12. Carroll ME, Meisch RA (1981) Determinants of increased drug self-administration due to food deprivation. Psychopharmacology 74:197–200Google Scholar
  13. Carroll ME, Stotz DC, Kliner DJ, Meisch RA (1984) Self-administration of orally-delivered methohexital in rhesus monkeys with phencyclidine or pentobarbital histories: Effects of food deprivation and satiation. Pharmacol Biochem Behav 20:145–151Google Scholar
  14. de la Garza R, Bergman J, Hartel CR (1981) Food deprivation and cocaine self-administration. Pharmacol Biochem Behav 15:141–144Google Scholar
  15. Lang WJ, Latiff AA, McQueen A, Singer G (1977) Self-administration of nicotine with and without a food delivery schedule. Pharmacol Biochem Behav 7:65–70Google Scholar
  16. Mabry PD, Campbell BA (1975) Potentiation of amphetamine induced arousal by food deprivation: Effects of hypothalamic lesions. Physiol Behav 14:85–88Google Scholar
  17. Martin A (1982) Acquisition and maintenance of pentobarbital self-injection behaviour in rats: Effects of bicuculline Ro 15/1788, naloxone and haloperidol. Honours thesis, La Trobe UniversityGoogle Scholar
  18. Oei TPS (1983) Effects of body weight reduction and food deprivation on cocaine self-administration. Pharmacol Biochem Behav 19:453–455Google Scholar
  19. Oei TPS, Singer G (1979) Effects of a fixed time schedule and body weight on ethanol self-administration. Pharmacol Biochem Behav 10:767–770Google Scholar
  20. Oei TPS, Singer G, Jefferys D (1980) The interaction of a fixed time food delivery schedule and body weight on self-administration of narcotic analgesics. Psychopharmacology 67:171–176Google Scholar
  21. Papasava M, Oei TPS, Singer G (1981) Low dose cocaine self-administration by naive rats: Effects of body weight and a fixed-time one minute food delivery schedule. Pharmacol Biochem Behav 15:485–488Google Scholar
  22. Papasava M, Singer G (1983) The effect of body weight and dose on phentermine self-administration in naive rats. Neurosci Lett Sup 11:67Google Scholar
  23. Pickens R (1968) Self-administration of stimulants by rats. Int J Addict 3:215–221Google Scholar
  24. Pickens R, Thompson T (1968) Cocaine reinforced behavior in rats: Effects of reinforcement magnitude and fixed-ratio size. J Pharmacol Exp Ther 161:122–129Google Scholar
  25. Pickens R, Thompson T, Yokel RA (1970) Characteristics of amphetamine self-administration by rats. In Ellinwood EH, Cohen S (eds) Current concepts of amphetamine abuse. US Govt Printing Office, Washington DC, pp 43–48Google Scholar
  26. Pilotto R, Singer G, Overstreet D (1984) Self-injection of diazepam in naive rats: Effects of dose, schedule and receptor blockade of different receptors. Psychopharmacology 84:174–177Google Scholar
  27. Singer G, Oei TPS, Wallace M (1982) Schedule-induced self-injection of Drugs. Neurosci Biobehav Rev 6:77–83Google Scholar
  28. Takahashi RN, Singer G (1979) Self-administration of Δ 9-Tetrahydrocannabinol by rats. Pharmacol Biochem Behav 11:737–740Google Scholar
  29. Takahashi RN, Singer G, Oei TPS (1978) Schedule induced self-injection of d-amphetamine by naive animals. Pharmacol Biochem Behav 9:857–861Google Scholar
  30. Yokel RA, Pickens R (1973) Self-administration of optical isomers of amphetamine and methylamphetamine by rats. J Pharmacol Exp Ther 187:27–33Google Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Micheal Papasava
    • 1
  • George Singer
    • 1
  1. 1.Department of PsychologyLa Trobe UniversityBundooraAustralia

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