, Volume 6, Issue 6, pp 475–479 | Cite as

Drug-induced decrement in spatial reversal learning in the white rat

  • Chester R. Wilpizeski
  • Charles L. Hamilton
Short Communications


This study investigated the effects of LSD-25, amphetamine sulfate and chlorpromazine on a simple spatial reversal learning problem in a water-filled maze. Following subcutaneous injections of 0.50 and 0.52 mg/ kg of LSD-25, albino rats were significantly handicapped in acquiring a reversed turning response. The performance of groups given 0.13 mg/kg LSD-25, 1 mg/kg chlorpromazine and 2 mg/kg amphetamine sulfate was not reliably different from a Ringer's-injected control group.


Sulfate Amphetamine Subcutaneous Injection Chlorpromazine Learning Problem 
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Copyright information

© Springer-Verlag 1964

Authors and Affiliations

  • Chester R. Wilpizeski
    • 1
    • 2
  • Charles L. Hamilton
    • 1
  1. 1.Veterans Administration HospitalCoatesville
  2. 2.Dept. of OtolaryngologyJefferson Medical College HospitalPhiladelphiaUSA

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