, Volume 32, Issue 4, pp 337–342 | Cite as

The effect of imipramine administered before and during pregnancy on litter size in the rat

  • G. Singer
  • I. R. Coyle
Animal Studies


Previous studies have suggested that anti-depressants administered during pregnancy result in an increase in foetal and neonatal morbidity. The present study examined the effects of the anti-depressant imipramine administered before and during pregnancy on litter size in the rat. Imipramine was found to cause a significant reduction in litter size with doses that are used therapeutically.

Key words

Imipramine Pregnancy Litter Size Teratogenicity 


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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • G. Singer
    • 1
  • I. R. Coyle
    • 1
  1. 1.Department of PsychologyLa Trobe UniversityBundooraAustralia

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