, Volume 1, Issue 6, pp 482–492 | Cite as

The effects of meprobamate, barbiturates, d-amphetamine and promazine on experimentally induced conflict in the rat

  • Irving Geller
  • Joseph Seifter
Original Investigations


Conflict behavior was induced in rats by simultaneously rewarding with liquid food and punishing with pain shock every lever response made in the presence of a tone. Meprobamate, phenobarbital and pentobarbital increased the number of shocks a rat would accept in order to obtain the food reward; in contrast, promazine and d-amphetamine decreased the number of shocks taken. The technique thus permits a separation on a behavioral basis of meprobamate, pentobarbital and phenobarbital from promazine and d-amphetamine.


Pentobarbital Phenobarbital Barbiturate Food Reward Liquid Food 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Conger, J. J.: The effects of alcohol on conflict behavior in the albino rat. Quart. J. Stud. Alcohol 12, 1–29 (1951).Google Scholar
  2. Fazekas, J. F.: Convulsant action of phenothiazine derivatives. J. Amer. med. Ass. 165, 1241 (1957).Google Scholar
  3. Ferster, C. B., and B. F. Skinner: Schedules of reinforcement. New York: Appleton-Century-Crofts 1957.Google Scholar
  4. Jacobsen, E.: In: Psychotropic Drugs (S. Garattini and V. Ghetti eds.). Milan: Elsevier 1957.Google Scholar
  5. Kurtzke, J. F.: Seizures with promazine. J. nerv. ment. Dis. 125, 119 (1957).Google Scholar
  6. Masserman, J. H., and K. S. Yum: An analysis of the influence of alcohol on experimental neurosis in cats. Psychosom. Med. 8, 36–52 (1946).Google Scholar
  7. Miller, N. E.: In: Psychotropic Drugs (S. Garattini and V. Ghetti eds.). Milan: Elsevier 1957.Google Scholar
  8. Naess, K., and Wulff Rasmussen: Approach-withdrawal responses and other specific behavior reactions as screening test for tranquillizers. Acta Pharmacol. (Kbh.) 15, 99–114 (1958).Google Scholar

Copyright information

© Springer-Verlag 1960

Authors and Affiliations

  • Irving Geller
    • 1
  • Joseph Seifter
    • 1
  1. 1.Wyeth Institute for Medical ResearchPhiladelphia 1

Personalised recommendations