A double-blind study was carried out in 30 patients to compare the results of chlorimipramine given orally and intravenously.
The speed of onset of action and the overall improvement were excellent for both treatment modalities. No significant differences were found favoring either way of administration. As a consequence, our results do not support previous reports that suggest advantages and rationale for the intravenous usage of chlorimipramine.
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Amat Aguirre, E.: Our experience in the treatment of depression with Anafranil. Comparative studies of the results achieved with I. V. infusions plus a single oral administration. Rev. Folia Neuropsychiat. 3, 1–8 (1968)
Collins, G. H.: I.V. Clomipramine in the treatment of severe depression. Brit. J. Psychiat. 117, 211–212 (1970)
Dickhaut, H. H.: Duration of treatment and dosage with Anafranil infusions, pp. 41–47. Symposium, Venedig 1968. Graz: Moser 1970
Klein, D.F., Davis, J.H.: Diagosins and treatment of psychiatric disorders. Baltimore: The Williams and Wilkins Co. 1969
Kugler, J.: Infusions of monochlorimipramine in depressed patients. Neurophysiological findings and results of therapy. Arzneimittel-Forsch. 19, 441–442 (1969)
Ledesma Jimeno, A., Borreguero, A. D., Fraile Sanchez, J.: Our experience with Anafranil in the treatment of depression. Actas IX, congreso nacional de neuropsiquiatria, Murcia, Spain, 1967, pp. 217–220 (1968)
Morel Maroger, A.: Anafranil IV in the initial treatment of depression, pp. 25–31. Graz: Moser 1970
Sigwald, J., Raymondeaud, C.: Treatment of depressive states with chlorimipramine, slow venous perfusions. Proc. IV World Congress and Psychiatry, Madrid 1966. Excerpta Med Found. Int Conf series, No. 150, Part 3, pp. 1850 to 1853 (1968)
Symes, M. H.: Monochlorimipramine: a controlled trial with a new antidepressant. Int. J. Neuropsychiat., pp. 60–67. January/February 1967
We thank Ms. Carol Umland, R. N. and Ms. Connie Ball, R. N. for their cooperation and dedication which made possible the successful completion of this study.
Also called Anafranil® abroad and Clomipramine in the U.S.A.
This investigation was supported in part by research grant MYP-5106 from the National Institute of Mental Health, U.S. Public Health Service.
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Escobar, J.I., Flemenbaum, A. & Schiele, B.C. Chlorimipramine: A double-blind comparison of intravenous versus oral administration in depressed patients. Psychopharmacologia 33, 111–116 (1973). https://doi.org/10.1007/BF00429081