Effects of d-amphetamine on the incorporation of carbon atoms of d-glucose into the brains of differentially-housed mice
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Mice were housed either individually (“isolated”) or in groups of 20–25 (“aggregated”) for 5–9 weeks or for 22 weeks. A decreased incorporation of radioactivity into brain from subcutaneously-administered U-14C-d-glucose occurred in “isolated” mice as compared to grouped animals. Amphetamine, administered before labelled glucose, produced a dose-dependent decrease of radioactivity which was selective to the brains of the “isolated” mice. The data support the correlation between isolation-induced changes in behavior and central metabolic pathways and indicate further that these changes may be altered by administration of psycho-active agents.
Key wordsd-Amphetamine Isolation Cerebral metabolism Environment
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