Advertisement

Psychopharmacologia

, Volume 45, Issue 2, pp 167–169 | Cite as

Effects of d-amphetamine on the incorporation of carbon atoms of d-glucose into the brains of differentially-housed mice

  • P. A. DeFeudis
  • R. M. Paolino
  • F. V. DeFeudis
Laboratory Studies

Abstract

Mice were housed either individually (“isolated”) or in groups of 20–25 (“aggregated”) for 5–9 weeks or for 22 weeks. A decreased incorporation of radioactivity into brain from subcutaneously-administered U-14C-d-glucose occurred in “isolated” mice as compared to grouped animals. Amphetamine, administered before labelled glucose, produced a dose-dependent decrease of radioactivity which was selective to the brains of the “isolated” mice. The data support the correlation between isolation-induced changes in behavior and central metabolic pathways and indicate further that these changes may be altered by administration of psycho-active agents.

Key words

d-Amphetamine Isolation Cerebral metabolism Environment 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bennett, E. L., Rosenzweig, M. R.: Chemical alterations produced in brain by environment and training. In: Handbook of neurochemistry, Vol. 6, A. Lajtha, ed., pp. 173–201. New York: Plenum Press 1971Google Scholar
  2. DeFeudis, F. V.: Effects of environmental changes on the incorporation of carbon atoms of d-glucose into mouse brain and other tissues. Life Sci. 10 (Part II), 1187–1194 (1971a)Google Scholar
  3. DeFeudis, F. V.: Studies on the content and metabolism of l-glutamate in peripheral nerve in vitro. Res. Commun. Chem. Path. Pharmacol. 2, 189–205 (1971b)Google Scholar
  4. DeFeudis, F. V.: Effects of isolation and aggregation on the incorporation of carbon atoms of d-mannose and d-glucose into mouse brain. Biol. Psychiat. 4, 239–242 (1972)Google Scholar
  5. DeFeudis, F. V.: Effects of d-amphetamine on the incorporation of carbon atoms of d-mannose into the brains and sera of differentially-housed mice; Short-term reversibility of these effects. Biol. Psychiat. 7, 3–9 (1973)Google Scholar
  6. DeFeudis, F. V.: Cerebral biochemical and pharmacological changes in differentially-housed mice. In: Current developments in psychopharmacology, Vol. I, W. B. Essman and L. Valzelli, eds. New York: Spectrum Publ. 1975Google Scholar
  7. DeFeudis, F. V., Black, W. C.: Effects of environment on the incorporation of radioactive carbon atoms of glucose into various structures of mice; evidence for diurnal rhythmicity. Exp. Neurol. 36, 41–45 (1972)Google Scholar
  8. DeFeudis, F. V., Marks, J. H.: Brain to serum distribution of radioactivity of injected 3H-d-amphetamine in differentially-housed mice. Biol. Psychiat. 6, 85–89 (1973)Google Scholar
  9. DeFeudis, F. V., Paolino, R. M.: Effects of environmental changes on the incorporation of carbon atoms of pyruvate into mouse brain and liver. Experientia (Basel) 28, 309–310 (1972)Google Scholar
  10. Essman, W. B.: Neurochemical changes associated with isolation and environmental stimulation. Biol. Psychiat. 3, 141–147 (1971)Google Scholar
  11. Valzelli, L.: Drugs and aggressiveness. In: Advances in pharmacology, Vol. 5, S. Garattini and P. A. Shore, eds., pp. 79–108. New York: Academic Press 1967Google Scholar

Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • P. A. DeFeudis
    • 1
    • 2
  • R. M. Paolino
    • 1
    • 2
  • F. V. DeFeudis
    • 1
    • 2
  1. 1.Institute of Psychiatric ResearchIndiana University School of MedicineIndianapolis
  2. 2.Department of Pharmacology and TherapeuticsPurdue UniversityLafayetteUSA

Personalised recommendations