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Piracetam in elderly psychiatric patients with mild diffuse cerebral impairment

Abstract

In a 12-week double-blind study, piracetam at two dose levels (2.4 and 4.8g/day) was compared to placebo in the treatment of 60 elderly psychiatric patients with mild diffuse cerebral impairment, but no signs of focal brain lesion. The psychiatric illness, schizophrenia or affective disorder, of patients selected was in remission at the time of the study. Monthly evaluations by the nurse revealed that piracetam improved overall functioning, particularly alertness, socialization, and cooperation, relative to the control group. Patients treated with 2.4g/day piracetam also showed significant improvement in scores for the full IQ and the memory quotient on the Wechsler Adult Intelligence and Memory Scales; greater response was seen in those with lower initial scores. Piracetam at 4.8g/day had a more rapid onset of action on behavioral variables than 2.4g/day, but its therapeutic effect tended to diminish at 12 weeks, possibly as the result of overstimulation. Piracetam did not appear to interfere with concomitant psychotropic maintenance medication or affect the psychiatric illness itself.

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References

  1. Abuzzahab FS Sr, Merwin GE, Zimmermann RL, Sherman MC (1977) A double-blind investigation of piracetam (Nootropil) vs. placebo in geriatric memory. Pharmacopsychiatria 10:49–56

  2. Asakura T, Ohnishi ST, Adachi K, Ozguc M, Hashimoto K, Devlin MT, Schwartz E (1981) Effect of piracetam on sickle erythrocytes and sickle hemoglobin. Biochem Biophys Acta 664:397–405

  3. Balsara JJ, Bapat TR, Chandorkar AG (1980) Effect of piracetam, a cyclic GABA analogue, on haloperidol-induced catalepsy, in the rat. Indian J Physiol Pharmacol 24:227–232

  4. Barnhart MI, Barmatoski SP, Pennek J (1979) Influence of piracetam on platelet structural physiology. Proceedings of the International Symposium on Nootropic Drugs, Rio de Janeiro, ed by Sociedade de Medicina and Cirurgia do Rio de Janeiro, Brazil, pp 227–241

  5. Bartus RT, Dean III RL, Sherman KA, Friedman E, Beer B (1981) Profound effects of combining choline and piracetam on memory enhancement and cholinergic function in aged rats. Neurobiol Aging 2:105–111

  6. Bartus RT (1981) Age-related memory loss and cholinergic dysfunction: Possible directions based on animal models. In: Crook T, Gershon S (eds) Strategies for the development of an effective treatment for senile dementia. Mark Powley, New Canaan, CT, pp 71–90

  7. Bente D, Glatthaar G, Ulrich g, Lewinsky M (1978) Elektroenzephalographische und klinische Ergebnisse einer Langzeitmedikation bei gerontopsychiatrischen Patienten. Arzneimittelforsch 28:1529–1530

  8. Bick RL, Skondia V (1979) Piracetam: Results of a preliminary in vivo trial as a platelet suppressant. Blood 54:234 (abstract)

  9. Burnotte RE, Gobert JG, Temmerman JJ (1973) Piracetam (2-pyrrolidinone acetamide) induced modifications of the brain polyribo-some pattern in aging rats. Biochem Pharmacol 22:811–814

  10. Chagnon M (1953) Manuel et Normes de l' Echelle d'Intelligence Ottawa-Wechsler. Editions de l'Universite d'Ottawa, Ontario

  11. Chagnon M (1955) Utilisation de l'Echelle d'Intelligence Ottawa-Wechsler. Editions de l'Universite d'Ottawa, Ontario

  12. Chouinard G, Annable L, Ross-Chouinard A, Kropsky M (1979) Ethopropazine and benztropine in neuroleptic-induced parkinsonism. J Clin Psychiatry 40:147–152

  13. Chouinard G, Ross-Chouinard A, Annable L, Jones BD (1980) Extrapyramidal Symptom Rating Scale. Can J Neurol Sci 7:233

  14. Davis JM, Cole JO (1975) Antipsychotic drugs. In: Freedman AM, Kaplan HI, Sadock BJ (eds) Comprehensive textbook of psychiatry, vol 2. Williams Wilkins, Baltimore, pp 1921–1941

  15. deMelo GOS (1976) Piracetam in sickle-cell anemia. Lancet II:1139–1140

  16. Dencker SJ, Lindberg D (1977) A controlled double-blind study of piracetam in the treatment of senile dementia. Nord Psykiatr Tidsskr 31:48–52

  17. Dimond SJ, Brouwers EYM (1976) Increase in the power of human memory in normal man through the use of drugs. Psychopharmacology 49:307–309

  18. Dimond SJ, Scammell RE, Pryce IG, Huws D, Gary C (1979) Some effects of piracetam (UCG 6215 Nootropyl) on chronic schizophrenia. Psychopharmacology 64:341–348

  19. Dorn M (1978) Piracetam bei vorzeitiger biologischer Alterung. Fortschr Med 96:1525–1530

  20. Ferris SH, Reisberg B, Friedman E, Schneck MK, Sherman KA, Mir P, Bartus RT (1982) Combination choline/piracetam treatment of senile dementia. Psychopharmacol Bull 18:94–98

  21. Friedman E, Sherman KA, Ferris SH, Reisberg B, Bartus RT, Schneck MK (1981) Clinical response to choline plus piracetam in senile dementia: Relation to red-cell choline levels. New Engl J Med 304:1490–1491

  22. Giurgea C (1973) The nootropic approach to the pharmacology of the integrative action of the brain. Cond Reflex 8:108–115

  23. Giurgea C, Lefevre D, Lescrenier C, David-Remacle M (1971) Pharmacological protection against hypoxia-induced amnesia in rats. Psychopharmacologia 20:160–168

  24. Gustafson L, Risberg J, Johanson M, Fransson M, Maximilian VA (1978) Effects of piracetam on regional cerebral blood flow and mental functions in patients with organic dementia. Psychopharmacology 56:115–118

  25. Guy W (ed) (1976) ECDEU Assessment manual for psychopharmacology. US Department of Health Education and Welfare, Rockville, MD

  26. Hakkarainen H, Hakamies L (1978) Piracetam in the treatment of postconcussional syndrome. Eur Neurol 17:50–55

  27. Itil TM, Kenon GN, Bozak M, Songar A (1982) The effects of oxiracetam (ISF 2522) in patients with organic brain syndrome (a double-blind controlled study with piracetam). Drug Dev Res 2:447–461

  28. Kretschmar JH, Kretschmar C (1976) Zur Dosis-Wirkungs-Relation bei der Behandlung mit Piracetam. Arneimittelforsch 26:1158–1159

  29. Lagergren K, Levander S (1974) A double-blind study on the effects of piracetam upon perceptual and psychomotor performance at varied heart rates in patients treated with artificial pacemakers. Psychopharmacologia 39:97–104

  30. Lecours AR, Lhermitte F (1979) Examen aphasiologique. In: Lecours AR, Lhermitte F (eds) Aphasie Les Presses de l'Universite de Montreal, Montreal, pp 463–493

  31. Lloyd-Evans S, Brocklehurst JC., Palmer MK (1979) Piracetam in chronic brain failure. Curr Med Res Opin 6:351–357

  32. Mindus P, Cronholm B, Levander SE, Schalling D (1976) Piracetaminduced improvement of mental performance. Acta Psychiatr Scand 54:150–160

  33. Nalbandian RM, Henry RL, Murayama M (1978) Sickle-cell disease: Two new therapeutic strategies. Lancet II:570–571

  34. Nalbandian RM, Henry RL, Burek L, Diglio CA (1981), Diminished adherence of sickle erythrocytes to rat and human vascular endothelium by piracetam. Blood 58:63 (abstract)

  35. Nickolson VJ, Wolthuis OL (1976), Effect of the acquisition-enhancing drug piracetam on rat cerebral energy metabolism. Biochem Pharmacol 25:2241–2244

  36. Nyback F, Wiesel A, Skett P (1979) Effects of piracetam on brain monoamine metabolism and serum prolactin levels in the rat. Psychopharmacology 61:235–238

  37. Osterrieth PA (1945) Le test de copie d'une figure complexe. Arch de Psychologie 30:205–353

  38. Overall JE, Gorham DR (1962) The Brief Psychiatric Rating Scale. Psychol Rep 10:799–812

  39. Pede JP, Schimpfessel L, Crokaert R (1971) The action of piracetam on the oxidative phosphorylation. Arch Int Physiol Biochim 79:1036–1037

  40. Pryce IG, Gray C (1978) Trial of piracetam in chronic schizophrenia. Br J Psychiatry 132:205

  41. Reisberg G, Ferris SH, Schneck MK, Corwin J, Mir P, Friedman E, Sherman KA, McCarthy M, Bartus RT (1982) Piracetam in the treatment of cognitive impairment in the elderly. Drug Dev Res 2:475–480

  42. Rey A (1941) L'examen psychologique dans les cas d'encephalopathie traumatique. Arch de Psychologie 28:286–340

  43. Richardson AE, Bereen FJ (1977) Effect of piracetam on level of consciousness after neurosurgery. Lancet II:1110–1111

  44. Rochus L, Reuse JJ (1972) Chlorpromazine, piracetam et métabolisme des phospholipides chez le rat. CR Soc Biol 166:975–978

  45. Schooler NR, Kane JM (1982) Research diagnoses for tardive dyskinesia. Arch Gen Psychiatry 39:486–487

  46. Shader RI, Harmatz JS, Salzman C (1974) A new scale for clinical assessment in geriatric populations: Sandoz Clinical Assessment-Geriatric (SCAG). J Am Geriatr Soc 22:107–113

  47. Sinha YN, Selby FW, Lewis UJ, Vanderlaan WP (1973) A homologous radioimmunoassay for human prolactin. J Clin Endocrinol Metab 36:509–516

  48. Sklenovsky A, Chmela Z (1980) The effects of piracetam on free fatty acids in the brain. Activ Nerv Super 22:197–198

  49. Spitzer RL, Endicott J, Robins E (1978) Research diagnostic criteria. New York State Psychiatric Institute, New York

  50. Stegink AJ (1972) The clinical use of piracetam, a new nootropic drug: The treatment of symptoms of senile involution. Arzneimittelforsch 22:975–977

  51. Targino deAraugo J, Nero GC (1977) Piracetam and acetamide in sicklecell disease. Lancet II:411

  52. Volavka J, Simeon J, Simeon S, Cho D, Reker D (1981) Effect of piracetam on EEG spectra of boys with learning, disorders. Psychopharmacology 72:185–188

  53. Wechsler D (1955) Manual for the Wechsler Adult Intelligence Scale. Psychological, Corporation. New York

  54. Winer BJ (1971) Statistical principles in experimental design. McGraw Hill, New York

  55. Woelk H (1979) Effects of piracetam on the incorporation of 32P into the phospholipids of neurons and glial cells isolated from rabbit cerebral cortex. Pharmacopsychiatrie 12:251–256

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Correspondence to G. Chouinard.

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Chouinard, G., Annable, L., Ross-Chouinard, A. et al. Piracetam in elderly psychiatric patients with mild diffuse cerebral impairment. Psychopharmacology 81, 100–106 (1983). https://doi.org/10.1007/BF00429000

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Key words

  • Piracetam
  • Nootropic drugs
  • Psychotropic drugs
  • Geriatrics
  • Aging
  • Cognitive impairment
  • Senile dementia