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The kinetics of β-granule formation: A morphometric study

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The rate of formation of β-granules in mouse islet cells has been studied by morphometry using experimental conditions in which insulin secretion is known to be blocked. The number of β-granules in a cell is increased by 120%, 45 minutes after a continued glucose stimulus of 16.7 mM. The implications of the results are discussed with respect to the construction of kinetic models for the secretion of insulin by exocytosis.


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Dean, P.M. The kinetics of β-granule formation: A morphometric study. Diabetologia 12, 111–114 (1976). https://doi.org/10.1007/BF00428974

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Key words

  • B-cell morphometry
  • kinetics of β-granule formation
  • exocytosis models
  • D-glucose-induced granule formation