, Volume 41, Issue 3, pp 277–284 | Cite as

Pharmacological interaction between cannabinol and δ9-tetrahydrocannabinol

  • R. N. Takahashi
  • I. G. Karniol
Animal Studies


The pharmacological activities of δ9-THC [(−)-δ9-trans-tetrahydrocannabinol], CBN (Cannabinol) and mixtures of δ9-THC + CBN were studied in rabbits, rats and mice.

CBN, although in general less active, mimicked the effects of δ9-THC in several pharmacological tests: corneal arreflexia in rabbits; climbing rope, open-field, irritability and aggressiveness after REM sleep deprivation in rats; catatonia, analgesia and sleeping time in mice.

When the mixture δ9-THC + CBN was used, a synergistic effect occurred on most of the depressant effects. On the other hand CBN did not interfere with or slightly inhibited the excitatory effects of δ9-THC. In the one peripheral test used, CBN did not alter the δ9-THC effect.

Key words

δ9-THC Cannabinol Cannabinoid Compounds Pharmacological Interaction 


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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • R. N. Takahashi
    • 1
  • I. G. Karniol
    • 1
  1. 1.Departamento de PsicobiologiaEscola Paulista de MedicinaS. PauloBrasil

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