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Psychopharmacologia

, Volume 41, Issue 3, pp 277–284 | Cite as

Pharmacological interaction between cannabinol and δ9-tetrahydrocannabinol

  • R. N. Takahashi
  • I. G. Karniol
Animal Studies

Abstract

The pharmacological activities of δ9-THC [(−)-δ9-trans-tetrahydrocannabinol], CBN (Cannabinol) and mixtures of δ9-THC + CBN were studied in rabbits, rats and mice.

CBN, although in general less active, mimicked the effects of δ9-THC in several pharmacological tests: corneal arreflexia in rabbits; climbing rope, open-field, irritability and aggressiveness after REM sleep deprivation in rats; catatonia, analgesia and sleeping time in mice.

When the mixture δ9-THC + CBN was used, a synergistic effect occurred on most of the depressant effects. On the other hand CBN did not interfere with or slightly inhibited the excitatory effects of δ9-THC. In the one peripheral test used, CBN did not alter the δ9-THC effect.

Key words

δ9-THC Cannabinol Cannabinoid Compounds Pharmacological Interaction 

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References

  1. Alves, C. N., Goyos, A. C., Carlini, E. A.: Aggressiveness induced by marihuana and other psychotropic drugs in REM sleep deprived rats. Pharmacol. Biochem. Behav. 1, 183–189 (1973)Google Scholar
  2. Borgen, L. A., Lott, G. C., Davis, W. M.: Cannabis induced hypothermia: a dose effect comparison of crude marihuana extract and synthetic δ9-tetrahydrocannabinol in male and female rats. Res. Com. Chem. Path. Pharmacol. 5, 621–627 (1973)Google Scholar
  3. Carlini, E. A., Masur, J.: Development of aggressive behavior in rats by chronic administration of Cannabis sativa (marihuana). Life Sci. 8 (part 1), 607–620 (1969)Google Scholar
  4. Carlini, E. A., Masur, J., Karniol, I. G., Leite, J. R.: II. Cannabis sativa: Is it possible to consider behavioral animal data as experimental models for some effects on humans? In: Cannabis and its derivatives, pharmacology and experimental psychology. Paton, W. D. M. and Crown, J., eds., pp. 154–175. London: Oxford University Press 1972Google Scholar
  5. Carlini, E. A., Karniol, I. G., Renault, P. F., Schuster, C. R.: Marihuana effects in laboratory animals and in human beings. Brit. J. Pharmacol. 50, 299–310 (1974)Google Scholar
  6. Eddy, N. B., Leimbach, D.: Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines. J. Pharmacol. exp. Ther. 107, 385–393 (1953)Google Scholar
  7. Fernandes, M., Coper, H.: The role of vehicles in cannabis application and interaction between cannabis and central active drugs. Acta pharm. suecica 8, 692–693 (1971)Google Scholar
  8. Frankenheim, J. M., McMillan, D. E., Harris, L. S.: Effects of δ9- and δ8-trans-tetrahydrocannabinol and cannabinol on schedule-controlled behavior of pigeons and rats. J. Pharmacol. exp. Ther. 178, 241–253 (1971)Google Scholar
  9. Grisham, M. G., Ferraro, D. P.: Biphasic effects of δ9-tetrahydrocannabinol on variable interval schedule performance in rats. Psychopharmacologia (Berl.) 27, 163–170 (1972)Google Scholar
  10. Hollister, L. E.: Marihuana in man: three years later. Science 172, 21–28 (1971)Google Scholar
  11. Karniol, I. G., Carlini, E. A.: The content of (−) δ9-transtetrahydrocannabinol does not explain all biological activity of some brazilian marihuana samples. J. Pharm. Pharmacol. 24, 833–835 (1972)Google Scholar
  12. Karniol, I. G., Carlini, E. A.: Pharmacological interaction between cannabidiol and δ9-tetrahydrocannabinol. Psychopharmacologia (Berl.) 33, 53–70 (1973)Google Scholar
  13. Karniol, I. G., Shirakawa, I., Kasinski, N., Pfefferman, A., Carlini, E. A.: Cannabidiol interferes with the effects of δ9-tetrahydrocannabinol in man. Europ. J. Pharmacol., submitted to publicationGoogle Scholar
  14. Krantz, J. C., Berger, H. J., Welch, B. L.: Blockade of (−)-trans-δ9-tetrahydrocannabinol depressant effect by cannabinol in mice. Amer. J. Pharmacol. 143, 149–152 (1971)Google Scholar
  15. Lapa, A. J., Sampaio, C. A. M., Timo-Iaria, C., Valle, J. R.: Blocking action of tetrahydrocannabinol upon transmission in the trigeminal system of the cat. J. Pharm. Pharmacol. 20, 373–376 (1968)Google Scholar
  16. Loewe, S.: Marihuana activity of cannabinol. Science 102, 615–616 (1945)Google Scholar
  17. Masur, J.: Sex differences in “emotionality” and behavior of rats in the open-field. Behav. Biol. 7, 749–754 (1972)Google Scholar
  18. Masur, J., Martz, R. M. W., Carlini, E. A.: Effects of acute and chronic administration of Cannabis sativa and (−)-δ9-trans-tetrahydrocannabinol on the behavior of rats in an open-field arena. Psychopharmacologia (Berl.) 19, 388–397 (1971)Google Scholar
  19. Mechoulam, R., Ben-Zvi, Z., Shani, A., Zemler, H., Levy, S., Edery, H., Grunfeld, Y.: Cannabinoids and Cannabis activity. In: Cannabis and its derivatives-pharmacology and experimental psychology, Paton, W. D. M., and Crown, J., eds., pp. 1–15. London: Oxford University Press 1972Google Scholar
  20. Nakamura, K., Thoenen, H.: Increased irritability: a permanent behavior change induced in the rat by the intraventricular administration of 6-hydroxytryptamine. Psychopharmacologia (Berl.) 24, 359–372 (1972)Google Scholar
  21. Poddar, M. K., Ghosh, J. J.: Effect of cannabis extract, δ9-tetrahydrocannabinol and lysergic acid diethylamide on rat liver enzymes. Biochem. Pharmacol. 21, 3301–3303 (1972)Google Scholar
  22. Potvin, R. J., Fried, P. A.: Acute and chronic effects on rats of (−)-δ1-trans-tetrahydrocannabinol on unlearned motor tasks. Psychopharmacologia (Berl.) 26, 369–378 (1972)Google Scholar
  23. Sofia, R. D., Kubena, R. K., Barry, H., III: Comparison of four vehicles for intraperitoneal administration of δ1-tetrahydrocannabinol. J. Pharm. Pharmacol. 23, 889–891 (1971)Google Scholar
  24. Willinsky, M. D., Scotti, A. C., Longo, V. G.: EEG and behavioral effects of natural synthetic and biosynthetic cannabinoids. Psychopharmacologia (Berl.) 31, 365–374 (1973)Google Scholar

Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • R. N. Takahashi
    • 1
  • I. G. Karniol
    • 1
  1. 1.Departamento de PsicobiologiaEscola Paulista de MedicinaS. PauloBrasil

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