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Does increasing stress change the behavioral action of mescaline from disruption to facilitation?

Abstract

This experiment is related to the hypothesis of Bridger and of Wray that hallucinogens have facilitatory effects on animal behavior when stress is part of the experiment and have disruptive effects otherwise. Male Long-Evans rats were trained to high (above 89%), stable base line rates of shuttlebox avoidance, then given each of four treatments at 6-day intervals after returning to base line avoidance rates: 1. saline (1 ml i.p.), 2. saline+stressor, 3. mescaline hydrochloride (39.6 mg/kg i.p.), 4. mescaline (39.6 mg/kg i.p.)+Stressor. Stress treatment was 1.0 mA footshock (1 sec duration) every 20–30 sec for 15 min between injection and session. Sessions (100 trials) began 20 min after injection. Treatments 1 and 2 had no effect on avoidance rate. Treatments 3 and 4 significantly decreased avoidance rate, with the latter causing significantly more decrease than the former. None of the treatments affected presession (5 min adaptation period) or intertrial crossings of the shuttlebox or latency on escape trials. These results suggest that exposure to a Stressor, per se, is not the crucial factor causing hallucinogens to have facilitatory effects on animal behavior.

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References

  1. Appel, J. B.: The effects of “psychotomimetic” drugs on animal behavior. In: Psychopharmacology, a review of progress, 1957–1967. D. E. Efron, ed., pp. 1211–1230. Washington: U.S.G.P.O. 1968

  2. Barry, H., III, Wagner, S. A., Miller, N. E.: Effects of several drugs on performance in an approach-avoidance conflict. Psychol. Rep. 12, 215–221 (1963)

  3. Bridger, W. H.: The interaction of stress and hallucinogenic drug action. Implications for a pathophysiological mechanism in schizophrenia. In: Schizophrenia: Current concepts and research. D. V. Siva Sankar, ed., pp. 470–476. Hicksville: PJD Publications 1967

  4. Bridger, W. H., Mandel, I. J.: Excitatory and inhibitory effects of mescaline on shuttle avoidance in the rat. Biol. Psychiat. 3, 379–385 (1971)

  5. Bridger, W. H., Stoff, D. M., Gorelick, D. A.: Stress changes the action of mescaline from behavioral inhibition to excitation. Paper presented at the Second Annual Meeting of the Society for Neuroscience, Houston, 1972

  6. Dutta, S. N., Ghosh, B., Pradhan, S. N.: Effects of commonly abused drugs on unpunished and punished behavior in rats. Pharmacologist 15, 237 (1973)

  7. Gorelick, D. A., Bozewicz, T.: Mescaline and shuttlebox escape/avoidance in rats: role of task and strain variables. J. de Pharmacol. 6, 131–142 (1975)

  8. McMillan, D. E.: Effects of drugs on punished and unpunished responding in pigeons. Pharmacologist 13, 207 (1971)

  9. Menon, M. K., Dandiya, P. C.: Behavioural and brain neurohormonal changes produced by acute heat stress in rats. Influence of psychopharmacological agents. Europ. J. Pharmacol. 8, 284–291 (1969)

  10. Sethy, V. H., Winter, J. C.: Effects of yohimbine and mescaline on punished behavior in the rat. Psychopharmacologia (Berl.) 23, 160–166 (1972)

  11. Smythies, J. R., Sykes, E. A.: The effect of mescaline upon the conditioned avoidance response in the rat. Psychopharmacologia (Berl.) 6, 163–172 (1964)

  12. Smythies, J. R., Bradley, R. J., Johnston, V. S.: Interaction of “stress” and the response to mescaline. Nature (Lond.) 215, 1179–1180 (1967)

  13. Stoff, D. M.: Multitrial passive avoidance in rats: mescaline, shock, and ITI effects. (Doctoral dissertation, Yeshiva University) Ann Arbor, Michigan: Xerox University Microfilms. No. 73-24801. [Dissertation Abstracts International (B) 34, 2348 (1973)]

  14. Stoff, D. M., Mandel, I. J., Gorelick, D. A., Bridger, W. H.: Acute and chronic effects of LSD and 3,4-dimethoxyphenylethylamine on shuttlebox escape/avoidance in rats. Psychopharmacologia (Berl.) 36, 301–312 (1974)

  15. Wray, S. R.: A correlative evaluation of cyclazocine, LSD and naloxone on continuous discriminated avoidance in rats. Psychopharmacologia (Berl.) 26, 29–43 (1972)

  16. Wray, S. R.: Interaction of stress and psychotomimetic drugaction: possible implication for psychosis. Psychopharmacologia (Berl.) 30, 263–268 (1973)

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Gorelick, D.A., Bridger, W.H. Does increasing stress change the behavioral action of mescaline from disruption to facilitation?. Psychopharmacologia 44, 307–309 (1975). https://doi.org/10.1007/BF00428913

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Key words

  • Mescaline
  • Stress
  • Shuttlebox Escape/Avoidance
  • Long-Evans Rats