, Volume 44, Issue 3, pp 215–224 | Cite as

Attenuation of the euphoriant and activating effects of d- and l-amphetamine by lithium carbonate treatment

  • Daniel P. Van Kammen
  • Dennis L. Murphy
Human Pharmacology


Seven of nine depressed patients experienced a 4.3-fold increase in rated euphoria and activation following 30 mg d-amphetamine in a replicated dose, double blind study. d-Amphetamine was 2 to 2.3-fold more effective in producing activation, euphoria, and antidepressant effects than the same dose of l-amphetamine.

Co-treatment with lithium carbonate produced a 60% (P<0.001) attenuation of the activation and euphoria responses to d-amphetamine. The responses to l-amphetamine were almost completely abolished by lithium. This study raises the possibility of lithium carbonate use as an adjunct in the treatment of amphetamine addiction.

Key words

d- and l-Amphetamine Lithium carbonate Depression Euphoria 


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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • Daniel P. Van Kammen
    • 1
  • Dennis L. Murphy
    • 1
  1. 1.Adult Psychiatry Branch and Laboratory of Clinical ScienceNational Institute of Mental HealthBethesda

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