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Levels of pyridoxine and susceptibility to electroconvulsive and audiogenic seizures


The effects of pyridoxine deficiency and the administration of supplemental vitamin B6 on audiogenic and electroconvulsive seizures were studied in two inbred strains of mice and their F1 hybrids. Pyridoxine deficient diets increased seizure risk, whereas supplemental vitamin B6 protected these animals against seizures. Penicillamine and thiosemicarbazide, at doses which lowered brain levels of pyridoxine by only 10%, increased seizure risk. Diets deficient in zinc and copper did not alter susceptibility to either audiogenic or electroconvulsive seizures. DBA/2J mice, genetically susceptible to audiogenic seizures, have the same endogenous levels of pyridoxine in the brain as do C57B1/6J mice, which are resistant to audiogenic seizures.

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The work reported in this paper was supported by grant number MH 13026 from the National Institute of Mental Health.

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Schlesinger, K., Lieff, B. Levels of pyridoxine and susceptibility to electroconvulsive and audiogenic seizures. Psychopharmacologia 42, 27–32 (1975).

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Key words

  • Pyridoxine
  • Audiogenic Seizures
  • Electroconvulsive Seizures