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Transposon-like structures in the Bacteriodes fragilis MLS plasmid pIP 410

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Homoduplexes of plasmid plP 410 encoding MLS resistance in Bacteroides fragilis strain 92 revealed two “transposon-like” structures:a 17.4 kb loop flanked by 0.75 inverted repeats, and a 4.5 kb loop flanked by 0.2 kb inverted repeats. The large structure is deleted in a derivative plasmid harboured by a MLS susceptible strain. We have also showed that the long and short inverted repcats are structurally related.

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  1. Bostein D, Kleckner N (1977) Translocation and illegitimate recombination by the tetracycline resistance element Tn 10. In: Bukhari AI, Shapiro JA, Adhya SL (eds) Cold Spring Harbor Laboratory, Cold Spring Harbor, pp 185–203

  2. Davis RW, Simon M, Davidson N (1971) Electron microscope heteroduplex methods for mapping regions of base sequence homology in nucleic acids. Methods Enzymol 21D:413–428

  3. Fiers W, Contreras R, Haegeman G, Rogiers R, Van de Voorde A, Van Heuverswyn H, Van Herreweghe J, Volckaert G, Ysebaert M (1978) Complete nucleotide sequence of SV 40 DNA. Nature 273:113–120

  4. Kleckner N (1977) Translocatable elements in procaryotes. Cell 11:11–23

  5. Privitera G, Dublanchet A, Sebald M (1979a) Transfer of multiple antibiotic resistance between subspecies of Bacterioides fragilis. J Infect Dis 139:97–101

  6. Privitera G, Sebald M, Fayolle F (1979b) Common regulatory mechanism of expression and conjugative ability of a tetracycline resistance plasmid in Bacteriodes fragilis. Nature 278:657–659

  7. Sanger F, Air GM, Barrell BG Brown NL, Coulson AR, Fiddes JC, Hutchinson CV III, Slocombe PM, Smith M (1977) Nucleotide sequence of bacteriophage Φx174 DNA. Nature 265:687–695

  8. Starlinger P (1978) DNA rearrangements in procaryotes. Ann Rev Genet 11:103–126

  9. Tally FP, Snydman DR, Gorbach SL, Malamy MH (1979) Plasmidmediated transferable clindamycin and erythromycin resistance in Bacteroides fragilis. J Infect Dis 139:83–88

  10. Welch RA, Kevin JR, Macrina L (1979) Transferable macrolide-lincosamide resistance in Bacteroides. Plasmid 2:261–268

  11. Welch RA, Macrina FL (1980) Deletion analysis of a transferable Bacteroides R-plasmid. In: Stuttard C, Rozee KR (eds) Plasmids and transposons. Environmental effects and maintenance mechanism. Academic Press, pp 137–144

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Correspondence to Michel Magot.

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Communicated by H. Saedler

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Magot, M., Fayolle, F., Privitera, G. et al. Transposon-like structures in the Bacteriodes fragilis MLS plasmid pIP 410. Molec. Gen. Genet. 181, 559–561 (1981). https://doi.org/10.1007/BF00428754

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  • Inverted Repeat
  • Large Structure
  • Susceptible Strain
  • Derivative Plasmid