Psychopharmacology

, Volume 47, Issue 1, pp 119–122 | Cite as

Effects of Δ9-Tetrahydrocannabinol and pentobarbital on a cortical response evoked during conditioning

  • E. S. Boyd
  • E. H. Boyd
  • L. E. Brown
Animal Studies Short Reports
Received:
Accepted:

Abstract

A surface-negative wave, evoked by tone cues, appeared in monkey post-arcuate cortex as the monkey learned that the cue signaled the availability of reward. This evoked activity was depressed, concomitantly with changes in the animal's behavioral responding, by doses of Δ9-tetrahydrocannabinol (Δ9-Tetrahydrocannabinol-THC) as low as 0.032 mg/kg and of pentobarbital as low as 4 mg/kg. Pentobarbital tended to increase the latency of the evoked wave, an effect not seen with Δ9-THC.

Key words

Frontal cortex Evoked activity Behavior Tetrahydrocannabinol Pentobarbital 
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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • E. S. Boyd
    • 1
  • E. H. Boyd
    • 1
  • L. E. Brown
    • 1
  1. 1.Department of Pharmacology and ToxicologyUniversity of Rochester, School of Medicine and DentistryRochesterU.S.A.

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