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Gabaergic modulation of mouse-killing in the rat

Abstract

When GABA-potentiating compounds were administered IP to rats with prior experience of mouse-killing behaviour, a reduction of killing was observed with gammavinyl GABA (200 and 400 mg/kg) and nipecotic acid amide (400 mg/kg), while no significant effect was noted following injection of dipropylacetate or THIP. The inhibitory effects of gamma-vinyl GABA and nipecotic acid amide were not reversed by subsequent injection of picrotoxin and were associated with sedation as observed in open field and actograph tests. When GABA-potentiating compounds were administered to food-deprived rats exposed for the first time to a mouse (initial elicitation), administration of gamma-vinyl GABA, dipropylacetate, nipecotic acid amide or THIP increased the incidence of mouse-killing behaviour. Conversely, the incidence of mouse-killing under the same conditions was reduced following injections of picrotoxin. These results do not support the hypothesis that the general activation of GABAergic mechanisms inhibits mouse-killing behaviour in rats. On the contrary, data obtained in naive animals suggest that potentiation of these mechanisms actually facilitates the initial elicitation of this behaviour.

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References

  1. Blavet N, De Feudis FV, Clostre F (1982) THIP inhibit feeding behaviour in fasted rats. Behav Neur Biol 34:109–112

  2. Bolin P, Da Vanzo JP (1982) The influence of isolation and aminooxyacetic acid (AOAA) on GABA in muricidal rats. Psychopharmacology 76:367–370

  3. Bowery NG, Hill DR, Hudson AL (1980) Characteristics of GABAb receptor binding sites on rat whole brain synaptic membranes. Br J Pharmacol 78:191–206

  4. Curtis DR, Duggan AW, Felix D, Johnston GAR (1970) GABA, bicuculline and central inhibition. Nature 226:1222–1224

  5. Da Vanzo JP, Sydow M (1979) Inhibition of isolation-induced aggressive behaviour with GABA-transaminase inhibitors. Psychopharmacology 62:23–27

  6. Delini-Stula A, Vassout A (1978) Modulatory effects of baclofen, muscimol and GABA on interspecific aggressive behaviour in the rat. Neuropharmacology 17:1063–1065

  7. Depaulis A, Vergnes M (1983) Induction of mouse-killing in the rat by intraventricular injection of a GABA-agonist. Physiol Behav 30:383–388

  8. Earley CJ, Leonard BE (1977) The effect of testosterone and cyproterone acetate on the concentration of gamma-aminobutyric acid in brain areas of aggressive and non-aggressive mice. Pharmacol Biochem Behav 6:409–413

  9. Enna SJ, Maggi A (1979) Biochemical pharmacology of GABAergic agonists. Life Sci 24:1727–1738

  10. Gallager DW, Thomas JW, Tallman JF (1978) Effect of GABAergic drugs on benzodiazepine binding site sensitivity in the rat cerebral cortex. Biochem Pharmacol 27:2745–2749

  11. Godin Y, Heiner L, Mark J, Mandel P (1969) Effects of di-n-propylacetate, an anticonvulsive compound on GABA metabolism. J Neurochem 16:869–873

  12. Haefely W, Pieri L, Polc P, Schaffner R (1981) General pharmacology and neuropharmacology of benzodiazepine derivatives. In: Hoffmeister F, Stille G (eds) Handbook of experimental pharmacology (vol 55, Psychotropic agents, part 2), Springer, Berlin, Heidelberg, New York, pp 13–262

  13. Horovitz ZP, Piala JJ, High JP, Burke JC, Leaf RC (1966) Effects of drugs on the mouse-killing (muricide) test and its relationship to amygdaloid function. Int J Neuropharmacol 5:405–411

  14. Huot S Palfreyman MG (1982) Effects of gamma-vinyl GABA on food intake of rats. Pharmacol Biochem Behav 17:107–110

  15. Jung MJ, Lippert B, Metcalf BW, Bohlen P, Schechter J (1977) Gamma-vinyl GABA, a new selective irreversible inhibitor of GABA-T: effect on brain GABA metabolism in mice. J Neurochem 29:797–802

  16. Karli P (1981) Conceptual and methodological problems associated with the study of brain mechanisms underlying aggressive behaviour. In: Brain PF, Benton D (eds) The biology of aggression. Sijthoff & Noordhoff International Publishers, Alphen aan den Rijn, pp 323–361

  17. Kimura H, Kuriyama K (1975) Distribution of gamma-aminobutyric acid in the rat hypothalamus: functional correlates of GABA with activities of appetite controlling mechanisms. J Neurochem 24:903–907

  18. Krogsgaard-Larsen P, Johnston GAR, Lodge D, Curtis DR (1977) A new class of GABA agonist. Nature 268:53–55

  19. Leaf RC, Wnek DJ, Gay PE, Corcia RM, Lamon S (1975) Chlordiazepoxide and diazepam induced mouse killing by rats. Psychopharmacologia 44:23–28

  20. Löscher W (1980) Effects of inhibitors of GABA transaminase on the synthesis, binding, uptake and metabolism of GABA. J Neurochem 34:1603–1608

  21. Mack G, Simler S, Mandel P (1975) Système inhibiteur gabanergique dans l'agressivité interspécifique rat-souris. J Physiol (Paris) 71:162A

  22. Mandel P, Mack G, Kempf E (1979) Molecular basis of some models of aggressive behaviour. In: Sandler M (ed) Psychopharmacology of aggression, Raven Press, New York, pp 95–110

  23. Olsen RW, Ban M, Miller T (1976) Studies on the neuropharmacological activity of bicuculline and related compounds. Brain Res 102:283–299

  24. Paul L, Miley WM, Mazzagati N (1973) Social facilitation and inhibition of hunger induced killing by rats. J Comp Physiol Pyschol 84:162–168

  25. Poshivalov VP (1981) Pharmaco-ethological analysis of social behaviour of isolated mice. Pharmacol Biochem Behav 14 (Suppl. 1):53–60

  26. Potegal M, Yoburn B, Glusman M (1983) Disinhibition of muricide and irritability by intraseptal muscimol. Pharmacol Biochem Behav 19:663–669

  27. Puglisi-Allegra S, Mandel P (1980) Effects of sodium n-dipropylacetate, muscimol hydrobomide and (R, S) nipecotic acid amide on isolation-induced aggressive behaviour in mice. Psychopharmacology 70:287–290

  28. Puglisi-Allegra S, Simler S, Kempf E, Mendel P (1981) Involvement of the GABAergic system on shock-induced aggressive behaviour in two strains of mice. Pharmacol Biochem Behav 14:13–18

  29. Quenzer LF, Feldman RS (1975) The mechanism of antimuricidal effects of chlordiazepoxide. Pharmacol Biochem Behav 3:567–571

  30. Roberts E (1978) Immunocytochemical visualization of GABA neurons. In: Lipton MA, DiMascio A, Killam KF (eds) Psychopharmacology: A generation of progress. Raven Press, New York, pp 95–102

  31. Rodgers RJ, Depaulis A (1982) GABAergic influences on defensive fighting in rats. Pharmacol Biochem Behav 17:451–456

  32. Siegel S (1956) Nonparametric statistics for the behavioral sciences. McGraw-Hill, New York

  33. Simler S, Gensburger C, Cielsielski L, Mandel P (1978) Time course of the increase in GABA level in different mice brain regions following n-dipropylacetate treatment. Commun Psychopharmacol 2:123–130

  34. Simler S, Puglisi-Allegra S, Mandel P (1982) Gamma aminobutyric acid in brain areas of isolated aggressive or non-aggressive inbred strains of mice. Pharmacol Biochem Behav 16:57–61

  35. Sofia RD (1969) Effects of centrally active drugs on four models of experimentally-induced aggression on rodents. Life Sci 8:705–716

  36. Sulcova A, Krsiak M, Mazek K (1981) Effects of calcium valproate and aminooxyacetic acid on agonistic behaviour in mice. Activ Nerv Super 23:287–288

  37. Tallman JF, Thomas JW, Gallager DW (1978) GABAergic modulation of benzodiazepine binding site sensitivity. Nature 274:383–385

  38. Ticku MK, Ban M, Olsen RW (1978) Binding of (3H) alphadihydropicrotoxinin, a gamma-aminobutyric acid synaptic antagonist, to rat brain membranes. Mol Pharmacol 14:391–402

  39. Valzelli L (1973) Activity of benzodiazepines on aggressive behaviour in rats and mice. In: Garattini S, Mussini E, Randall L (eds) The benzodiazepines. Raven Press, New York, pp 405–417

  40. Van der Laan JW, De Boer J, Bruinvels J (1979) di-n-propylacetate and GABA degradation: preferential inhibition of succinie semialdehyde dehydrogenase and indirect inhibition of GABA transaminase. J Neurochem 32:1769–1780

  41. Van Hemel PE (1972) Aggression as a reinforcer: operant behaviour in the mouse-killing rat. J Exp Anal Behav 17:237–245

  42. Vergnes M (1981) Effect of prior familiarization with mice on elicitation of mouse-killing in rats: role of the amygdala. In: Ben-Ari Y (ed) The amygdaloid complex, INSERM Symposium XX. Elsevier/North-Holland Biomedical press, Amsterdam, pp 293–304

  43. Vergnes M, Marescaux C, Micheletti G, Depaulis A, Rumbach L, Warter JM (1984) Enhancement of spike and wave discharges by GABA-mimetic drugs in rats with spontaneous Petit-Mal like epilepsy. Neurosci Lett 44:91–94

  44. Wermuth CG, Mack G, Mandel P (1980) Synergy or potentiation of sodium valproate and an inhibitor of GABA uptake. Brain Res Bull 5 (Suppl. 2):601–603

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Correspondence to Marguerite Vergnes.

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Depaulis, A., Vergnes, M. Gabaergic modulation of mouse-killing in the rat. Psychopharmacology 83, 367–372 (1984). https://doi.org/10.1007/BF00428547

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Key words

  • GABA
  • Mouse-killing
  • Aggressive behaviour
  • GVG
  • DPA
  • THIP
  • Picrotoxin
  • Bicuculline
  • Rat